SASH1基因研究进展  

Research progress of SASH1 gene

作　　者：刘秋菊[1] 贺远龙[1] 许琳[1] 赵丽萍[1] 王青[1] 

机构地区：[1]青岛大学医学院附属青岛市市立医院东院消化科,山东省266071

出　　处：《中华临床医师杂志（电子版）》2013年第22期161-163,共3页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金青年科学基金资助项目(81101813)

摘　　要：SASH1(SAM-and SH3-domain containing 1)基因是进化保守的SLY基因家族的一员,广泛表达于人体多种正常组织(淋巴样干细胞除外)。其可通过调节细胞生长、增殖和凋亡等,参与多种疾病的发生发展。本文对SASH1基因的分子结构、功能、调节通路及与肿瘤等疾病的关系作一综述。SASH1 gene, a member of the evolutionarily conserved SLY-family, is widely expressed in normal human tissue, with the exception of lymphoblastoid cells. SASH1 gene played an important role in the development and progression of various diseases by regulating the cell growth, proliferation and apoptosis. The molecular structure, function, regulation passageway and the relationship with tumors of SASH1 gene have been detailed reviewed.

关 键 词：信号传导 肿瘤 综述文献(主题) SASH1基因 

分 类 号：R730.2[医药卫生—肿瘤]