VEGF、EGFR和Ki-67在青年乳腺癌中的表达及与临床病理分期的关系  

Expressions of VEGF,EGFR and Ki-67 in young breast carcinoma and relationship with the clinical pathologial stage

作　　者：余文杰[1] 沈孝坤[2] 

机构地区：[1]浙江省台州医院肿瘤外科,浙江临海317000 [2]温州医学院附属台州医院,浙江临海317000

出　　处：《中国现代医生》2014年第2期26-29,共4页China Modern Doctor

基　　金：国家自然科学基金(32500301-333-0)

摘　　要：目的探讨青年乳腺癌患者VEGF、EGFR和Ki-67的表达以及与临床病理特征的相关性。方法回顾性分析≤35岁乳腺癌患者的临床资料,分析VEGF、EGFR和Ki-67的表达水平及临床病理特征。结果青年组VEGF、EGFR和Ki-67的阳性表达率显著高于中老年组患者(P<0.01或P<0.05)。VEGF、EGFR和Ki-67的表达与肿瘤TNM分期和腋窝淋巴结转移个数具有相关性(P<0.01)。结论 VEGF、EGFR和Ki-67在青年乳腺癌患者中呈高表达,并且其阳性表达率与患者的TNM分期和腋窝淋巴结转移具有相关性。Objective To discuss expression of VEGF,EGFR and Ki-67 in youth breast cancer and the relationship with TNM. Clinical data of patients with breast cancer aged ~〈35 were analyzed. Expressions of VEGF,EGFR and Ki- 67 and clinicopathologic feature were analyzed. Results Expressions rates of VEGF,EGFR and Ki-67 in youth group were higher than elderly group （P〈0.01 or P〈0.05）. Expressions of VEGF,EGFR and Ki-67 showed correlation with TNM and the number of lymph node metastasis （P〈0.01）. Conclusion Expressions of VEGF,EGFR and Ki-67 in youth breast cancer are high. Positive expressions show correlation with TNM and the number of lymph node metastasis.

关 键 词：乳腺癌 血管内皮生长因子 表皮生长因子受体 非组蛋白核蛋白 

分 类 号：R737.9[医药卫生—肿瘤]