聚乙烯醇复合水凝胶外用膜剂的制备与性能  

The Preparation and Properties of Poly(vinyl Alcohol)-Dex-CMC Hydrogel Patch

作　　者：冯艳[1] 吴造展[1] 陈丽竹[1] 徐建雄[1] 郭秋圆[1] 黄袭雯[1] 袁伟恩[1] 

机构地区：[1]上海交通大学药学院,上海200240

出　　处：《现代生物医学进展》2014年第2期244-246,共3页Progress in Modern Biomedicine

基　　金：国家重大专项-"重大新药创制"科技重大专项-创新药物研究开发技术平台(2009ZX09310-007);国家自然科学基金项目(81173001);上海科委纳米专项(11nm0503300;1052nm03900)

摘　　要：目的:考察PVA/葡聚糖/羧甲基纤维素钠复合水凝胶外用膜剂的制备方法,并与纯PVA水凝胶贴膜进行对比,考察本膜剂在物理性能和药物体系的体外释放行为上所具备的优越性。方法:利用冷冻-解冻物理交联方法制备水凝胶装载胰岛素模型药物的外用膜剂,通过万能拉力机和差示扫描量热法考察膜剂的物理性能,利用高效液色谱法考察该膜剂的体外释放行为。结果:PVA复合水凝胶外用贴膜相较于纯PVA水凝胶贴膜的韧性减小、刚性增加,体外释放变好。结论:通过将具有材料友好性的PVA和多糖葡聚糖、羧甲基纤维素钠合并使用制备胰岛素复合水凝胶贴膜,既能保证贴膜具有良好的物理性能,又具有较好地释放行为,优于目前文献报道的纯PVA水凝胶贴膜性能,有望继续研究优化性能。Objective： Investigation the preparation of PVA/glucan/sodium carboxymethyl cellulose composite hydrogel for external use, and comparing with pure PVA hydrogel in physical properties and drug system in vitro release. Methods： Make use of freeze - thaw physical crosslinking methods preparation hydrogel loading insulin model drug requests for external use, through the universal tensile machine and differential scanning calorimetry study the requests of physical properties, the use of HPLC on the requests of the in vitro release behavior. Result： PVA composite hydrogel for external use paster compared with pure PVA hydrogel paster toughness decrease, rigid increase, the in vitro release better. Conclusion： Through the amalgamation of material friendly PVA and polysaccharide glucan,sodium carboxymethyl, the insulin composite hydrogel paster has not only good physical properties, but also good release behavior and is better than the performance of the current pure PVA hydrogel paster which current literature reports, and is expected to continue to study optimization performance.

关 键 词：聚乙烯醇水凝胶 胰岛素 葡聚糖 羧甲基纤维素 物理性能 体外释放 

分 类 号：R914[医药卫生—药物化学]