认知疗法联合舍曲林治疗产后抑郁症患者的临床疗效研究  

Research on the Clinical Effect of Cognitive Behavioral Therapy Combined with Sertralin on the Postpartum Depression

作　　者：唐英[1] 陈玖[2] 黄平[1] 杨来启[2] 李兰兰[2] 

机构地区：[1]成都市新都区妇幼保健院妇产科,四川成都610500 [2]解放军第三医院全军精神疾病防治中心,陕西宝鸡721004

出　　处：《现代生物医学进展》2014年第2期333-335,332,共4页Progress in Modern Biomedicine

基　　金：军队中医药科研专项课题(10ZYX108)

摘　　要：目的:探讨认知疗法合并舍曲林治疗产后抑郁症患者的临床疗效。方法:将本院2011年10月至2012年7月收治的76例产后抑郁症患者按随机数字表法分为认知疗法合并舍曲林治疗组(试验组,38例)和舍曲林单独治疗组(对照组,38例),进行临床随机双盲对照试验,采用17项汉密尔顿抑郁量表(Hamilton Depression Rating Scale,HAMD)、临床整体量表-疗效总评估量表(Clinical Global Impression,CGI)评价和比较两组的临床疗效。结果:(1)试验组的有效率显著高于对照组,差异有统计学意义[92.11%vs 81.58%),P<0.01],试验组第2、3阶段的临床有效率均显著高于对照组,差异有统计学意义(P<0.05)。(2)与治疗前相比,两组患者治疗后的HAMD、CGI-SI总分均降低,差异有统计学意义(P<0.01);治疗第1、2、3阶段,试验组HAMD、CGI-SI减分值均显著高于对照组,差异有统计学意义(P<0.05)。结论:认知疗法联合舍曲林治疗产后抑郁症的短期治疗内疗效显著优于舍曲林单独治疗。Objective： To investigate the clinical effect of cognitive behavioral thempy （CBT） combined with Sertralin and single Sertralin on the postpartum depression. Methods： 76 cases of ostpartum depression patients hospitalized from October 2011 to July 2012 were enrolled and divided into the cognitive behavioral thempy combined with Sertralin treated group （experimental group, n=38） and Sertralin treated group （control group, n=38） by the method of the random number table. Clinical randomized double blind control test was performed and 17-item Hamilton Depression Rating Scale （HAMD） and Clinical Global Impression （CGI）. We used to evaluate and compare the clinical effect between two groups. Results： （1） The effective rate in the experimental group was significantly higher than that in the control group [（92.11% vs 81.58 %）, P〈0.01 ]. The curative effects in the second and thirdly phase of the experimental group were significantly better than those of the control group （P〈0.05）. （2） Compared with prior-treatment, the HAMD and CGI-SI scores of patients were decreased significantly post-treatment （P〈0.01）. The reductive score value of HAMD and CGI-SI of experimental group during three phase were significantly better than thoseof the control group （P〈0.05）. Conclusion： Cognitive behavioral therapy combined with Sertralin was superior to single Sertralin in short-term treatment.of postpartum depression.

关 键 词：认知行为疗法 舍曲林 产后抑郁症 临床疗效 

分 类 号：R749.4[医药卫生—神经病学与精神病学]