Does Aliskiren Influence the Changes of Global Longitudinal Strain in Patients with Diastolic Dysfunction？  

作　　者：Emil Ivanov Manov Nikolay Margaritov Runev Stefan Naydenov Naydenov Rabhat Ahmed Shabani Temenuga Ivanova Donova 

机构地区：[1]Department of lnternal Diseases, Clinic of Cardiology, Medical University, Sofia 1431, Bulgaria

出　　处：《Journal of US-China Medical Science》2013年第5期146-152,共7页美中医学（英文版）

摘　　要：The aim of our study was to investigate the effects of Aliskiren on the blood pressure values as well as on the myocardial function, assessed by GLS （global longitudinal strain） in patients with uncontrolled AH （arterial hypertension） and diastolic dysfunction. Forty five nondiabetic patients （29 men and 16 women, mean age 58.7 ± 12.4 years） with BP （blood pressure） 〉 140/90 mm Hg despite of combined antihypertensive therapy （diuretic, calcium channel blockers, beta-blockers） were evaluated. All of them had echocardiographic data for diastolic dysfunction： E/E＇ ratio _〈 8, E/A ratio 〈 0.8, DT （deceleration time） 〉 200 ms. Aliskiren 2 x 150 mg per day was added to the previous therapy. The follow-up period was 1 year, including monthly clinical visits. Echocardiographic assessment of the left ventricular function by longitudinal strain and Doppler analysis of the transmitral blood flow was performed at months 1, 6 and 12. The baseline mean measurements of systolic and diastolic BP values showed （153.4 ± 14.4）/（99.2 ±6.7） mmHg for males and （157.6 ±12.5）/（97.3±8.2） mmHg for females. The systolic and diastolic BP values at the end of the 1st month were （131.7±7.4）/（83.6± 5.2） mmHg in men and （132.4± 5.3）/（81.8± 6.9） mmHg in women （P 〈 0.05, compared to the initial BP values）. The baseline ratio of E/E＇ was found to be 6.5 ± 0.9, E/A-0.6±0.01 and DT--258 ± 32.7 ms. The values of these parameters at month 12 were as follows： E/E＇--7.0± 0.64, E/A--0.7± 0.05, DT--239 ± 16.5 ms （P = NS）. Baseline global longitudinal strain in men was -10.4 ±0.7% and -11.0 ± 0.9% in women, whereas GLS at month 12 showed values of： （-16.3± 0.9%） and （-17.5 ± 0.7%） for males and females respectively （P 〈 0.05）. During the whole period of treatment with Aliskiren and follow-up no adverse effects were registered. Aliskiren, added to a combined antihypertensive therapy （without RAAS--renin-angiotensin-aldosterone system bloc

关 键 词：ALISKIREN arterial hypertension diastolic dysfunction global longitudinal strain. 

分 类 号：S854.42[农业科学—临床兽医学] TQ463[农业科学—兽医学]