云南高校图书馆联盟文献共享服务平台- ALISKIREN

ALISKIREN: 作品数：33被引量：47H指数：4; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李兆欣孙铁民冷玲颖郭燕舞法志强更多>>; 相关机构：青岛大学华东理工大学沈阳药科大学天津市环湖医院更多>>; 相关期刊：《Advances in Enzyme Research》《Chinese Medical Journal》《Open Journal of Nephrology》《心血管病学进展》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划山东省中医管理局资助课题辽宁省科技厅基金更多>>

Mechanism Study of Aliskiren and Its Analogues by Molecular Dynamic Simulation: 《Chinese Journal of Structural Chemistry》2022年第3期178-185,I0012,共9页YAN Wen-Li LIANG Zhen YU Xing-Lian ZHANG Rong; supported by Talents Introduction Foundation for Universities of Guangdong Province (GD 2011);the Science and Technology Planning Project of Guangzhou (No. 2013J4100071); The further interaction mechanism towards renin inhibitors was revealed by comparison of renin with different active inhibitors in aqueous solution.Molecular docking and molecular dynamics(MD)simulations were combined...; 关键词：renin inhibitors MECHANISM molecular docking molecular dynamics(MD)simulations

Aliskiren单用及联用氟伐他汀对动脉粥样硬化斑块稳定性的影响被引量：2: 《现代生物医学进展》2019年第12期2201-2206,共6页吴宏宪成宪武马元吉 Murohara Toyoaki 钱菊英葛均波; 国家重点研究发展计划项目(2016YFC1301200);国家自然科学基金项目(81800380);复旦大学附属中山医院青年基金项目(2018ZSQN03); 目的:观察和比较肾素抑制剂aliskiren单用或与氟伐他汀(fluvastatin)联用对动脉粥样硬化斑块稳定性的影响。方法:选择4周龄雄性ApoE-/-小鼠通过喂以高脂饮食8周建立动脉粥样硬化模型,将其随机分为5组:模型对照组、aliskiren组、肼屈嗪...; 关键词：肾素抑制剂 ALISKIREN 动脉粥样硬化氟伐他汀血管新生斑块稳定性

Aliskiren抑制LPS诱导HUVECs新生血管的形成及可能机制被引量：1: 《中国病理生理杂志》2016年第4期602-609,共8页李兆欣刘江月王其新; 山东省中医药管理局资助项目(No.2013-237);青岛市民生计划项目(No.13-1-4-139-jch); 目的:研究阿利吉仑(aliskiren)对脂多糖(LPS)诱导人脐静脉内皮细胞(HUVECs)新生血管形成能力的影响及可能的机制。方法:常规培养的HUVECs随机分为空白组和肾素组,ELISA法测定炎性细胞因子肿瘤坏死因子-α(TNF-α)和细胞间黏附分子-1(ICA...; 关键词：阿利吉伦新生血管形成炎症反应 TOLL样受体4 肾素

直接肾素阻滞剂Aliskiren预防早产儿视网膜病变被引量：1: 《眼科新进展》2015年第4期393-396,共4页马誉铷刘鹤南底煜陈晓隆; 辽宁省科技厅基金资助(编号:2013225049);沈阳市科技专项基金资助(编号:F13-220-9-37)~~; 肾素作为肾素-血管紧张素系统(renin-angiotensin system,RAS)中上游生长因子,对RAS链起着特异性限速的作用。在早产儿视网膜病变等缺血性视网膜病变中,RAS上调,视网膜RAS被激活,刺激血管内皮生长因子等上调,导致血管渗漏、血管内皮细...; 关键词：肾素-血管紧张素系统视网膜病早产儿 ALISKIREN 血管内皮生长因子

Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice被引量：12: 《Acta Pharmacologica Sinica》2014年第8期1005-1014,共10页Li-qing WENG Wen-bin ZHANG Yong YE Pei-pei YIN Jie YUAN Xing-xu WANG Le KANG Sha-sha JIANG Jie-yun YOU Jian WU Hui GONG Jun-bo GE Yun-zeng ZOU; We would li~ke to thank Mr Guo-ping ZHANG at the Insti- tute of Biomedical Science, Fudan University for his technical assistance. This work was supported by grants from the Key Program of National Natural Science Foundation of China （No 30930043）, the Key International （Regional） Joint Research Program of National Natural Science Foundation of China （No 81220108003）, and the Key Basic Research Program of Shanghai （No 11JC1402400）, which were awarded to Yun-zeng ZOU. Meanwhile, it was supported by the grant from Natural Science Foundation of Zhejiang Province of China （No LQ14H020002）, which was awarded to Wen-bin ZHANG.; Aim： Aliskiren （ALK） is a renin inhibitor that has been used in the treatment of hypertension. The aim of this study was to determine whether ALK could ameliorate pressure overload-induced heart hypertrophy and fib...; 关键词：ALISKIREN RENIN cardiac hypertrophy pressure overload autophagy angiotensin II PKC ERK1/2 3-methyladenine LY333531 CARDIOMYOCYTE

Aliskiren Augments the Activities of Anti-Oxidant Enzymes in Liver Homogenates of DOCA Salt-Induced Hypertensive Rats: 《Advances in Enzyme Research》2014年第2期92-99,共8页Sahar Kamal; Hypertension is a serious problem that is recently thought to be associated with damaging effects on target organs partially via oxidative stress. On the other hand, there is accumulating literature describing some so...; 关键词：ALISKIREN DOCA HYPERTENSIVE Rats ANTI-OXIDANT Enzymes TBARS Liver

Antiproteinuric Effect of Aliskiren versus Losartan in Primary Glomerulonephritis: 《Open Journal of Nephrology》2014年第2期61-68,共8页Abdul Halim Abdul Gafor Azrini Abdul Aziz Rozita Mohd Rizna Abdul Cader Kong Wei Yen Shamsul Azhar Shah Norella C. T. Kong; Introduction: Treatment with renin-angiotensin-aldosterone-system (RAAS) blockers plays a major role in halting chonic kidney disease (CKD) progression. Aliskiren is the first orally available direct renin inhibitor (...; 关键词：Primary GLOMERULONEPHRITIS HYPERTENSION PROTEINURIA ALISKIREN LOSARTAN

Aliskiren ameliorates sympathetic nerve sprouting and suppresses the inducibility of ventricular tachyarrhythmia in postinfarcted rat heart: 《Chinese Medical Journal》2013年第24期4707-4714,共8页JIA Yin-yu BAO Zhi-wei WEI Mei-fang ZHU Jian-hua GUI Le; This study was supported by grants trom Natural Science Foundation of China （No. 30971223） and Nantong Society Development Project （No. 2010008）.; Background Aliskiren is an oral renin inhibitor, which inhibits the first rate limiting step in the renin angiotensin aldosterone system. In this study, sympathetic nerve sprouting and the inducibility of ventricular ...; 关键词：sympathetic nerve myocardial infarction aliskiren ventricular fibrillation

Does Aliskiren Influence the Changes of Global Longitudinal Strain in Patients with Diastolic Dysfunction？: 《Journal of US-China Medical Science》2013年第5期146-152,共7页Emil Ivanov Manov Nikolay Margaritov Runev Stefan Naydenov Naydenov Rabhat Ahmed Shabani Temenuga Ivanova Donova; The aim of our study was to investigate the effects of Aliskiren on the blood pressure values as well as on the myocardial function, assessed by GLS （global longitudinal strain） in patients with uncontrolled AH （ar...; 关键词：ALISKIREN arterial hypertension diastolic dysfunction global longitudinal strain.

Aliskiren预处理对脑缺血再灌注损伤的保护及对脑能量代谢的影响被引量：2: 《中华神经外科杂志》2013年第6期626-631,共6页张涛法志强郭燕舞; 国家自然科学基金（30901546/H0912）; 目的探讨Aliskiren预处理对脑缺血再灌注（I／R）损伤的保护作用及对脑能量代谢的影响。方法将雄性ICR小鼠随机分为假手术组（Sham组）、溶剂对照组（Vehicle组）、低剂量Aliskiren预处理组（Alis．L组）和高剂量Aliskiren预处理组（Ali...; 关键词：ALISKIREN 脑缺血再灌注损伤能量代谢细胞凋亡

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