低阻抗意念导入疗法治疗抑郁症的电生理机制探讨  

Electronic physiological mechanism of low resistance thought induction psychotherapy（TIP） on depression

作　　者：林颖娜[1] 洪兰[1] 赵阳[1] 李涛[1] 吕学玉[1] 李桂侠[1] 汪卫东[1] 

机构地区：[1]中国中医科学院广安门医院心理科,北京100053

出　　处：《国际中医中药杂志》2014年第2期107-109,共3页International Journal of Traditional Chinese Medicine

基　　金：国家自然基金项目（项目编号：30772845）

摘　　要：目的 初步探讨低阻抗意念导入疗法（TIP）治疗抑郁症的电生理机制.方法 将48例抑郁症患者采用随机信封法随机分为低阻抗状态下的意念导入疗法组（TIP组）24例,采用低阻抗状态下意念导入疗法治疗;氢溴酸西酞普兰片组24例,采用氢溴酸西酞普兰片治疗.两组疗程均为6个月,采用汉密尔顿抑郁量表（HAMD）评定疗效,多导睡眠图（PSG）探索电生理机制.结果 TIP组可以减少觉醒次数[疗前（3.92±3.24）次、疗后（2.38±1.21）次,P＜0.05]、缩短REM期睡眠时间[分别为疗前（86.75±28.29） min、疗后（63.19±28.11）min,P＜0.01]、降低REM睡眠百分比[疗前（23.89±6.84）％、疗后（16.16±6.36）％,P＜0.01]、降低NREM睡眠百分比[疗前（76.15±6.80）％、疗后（83.83±6.26）％,P＜0.05].氢溴酸西酞普兰片组可增加总睡眠时间[疗前（350.52±50.71）min、疗后（388.58±43.89） min,P＜0.01]、REM期次数[疗前（3.71±2.87）次、疗后（5.17±5.58）次,P＜0.05]、3＋4期睡眠时间[疗前（35.79±32.76） min、疗后（56.77±34.21）min,P＜0.05]、3＋4期睡眠百分比[疗前（10.13±9.20）％、疗后（14.53±8.66）％,P＜0.05]、REM期睡眠时间[（疗前（66.39±29.22） min、疗后（78.61±30.19） min,P＜0.05].TIP对觉醒次数、REM期时间的改善明显优于氢溴酸西酞普兰组.结论 TIP治疗抑郁症的电生理机制为减少觉醒次数、缩短REM期睡眠时间、降低REM睡眠百分比.Objective To observe the electronic physiological mechanism of Low Resistance Thought Induction Psychotherapy （TIP） on depression.Methods 48 patients with depression were randomly divided into TIP group and Citalopram group.The observation period was 6 months.The Hamilton Rating Scale for Depression（HAMD） was used to evaluate the efficacy,and Polysomnogram（PSG）was used to evaluate the electronic physiological mechanism.Results TIP had efficacy on reducing numbers of wake [before treatment （3.92±3.24）,after treatment （2.38± 1.21）,P＜0.05]、REM time [before treatment （86.75 ±28.29）,after treatment （63.19±28.11）,P＜0.01]、REM％ [before treatment （23.89±6.84）,after treatment （16.16±6.36）,P＜0.01].Citalopram had efficacy on increasing Sleep time [before treatment （350.52±50.71）,after treatment （388.58±43.89）,P＜0.01]、number of REM [before treatment （3.71±2.87）,after treatment （5.17±5.58）,P＜0.05]、S3＋4 [before treatment （35.79±32.76）,after treatment （56.77±34.21）,P ＜0.05]、S3 ＋4％ [before treatment （10.13 ± 9.20）,after treatment （14.53 ± 8.66）,P＜0.05]、REM time [before treatment （66.39±29.22）,after treatment（78.61 ±30.19）,P＜0.05].TIP had superior to Citaloprarn on regulating numbers of wake and REM time.Conclusions Electronic physiological mechanism of TIP treating depression is to regulat numbers of wake,REM time,REM％.

关 键 词：低阻抗状态下的意念导入疗法 抑郁症 电生理机制 

分 类 号：R749.4[医药卫生—神经病学与精神病学]