电压门控钠离子通道疾病的研究进展  

Research Advances on Voltage-gated Sodium Channels Disease

作　　者：陈程浩[1] 周桃[1] 云慧[1] 刘新星[1] 谢建平[1] 

机构地区：[1]中南大学资源加工与生物工程学院,湖南长沙410083

出　　处：《现代生物医学进展》2013年第30期5995-6000,共6页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(51104189)

摘　　要：细胞膜上的电压门控钠离子通道(Voltage-gated Sodium Channels,VGSCs)是细胞形成动作电位过程中重要的组成构件,由一个大的α亚基和一个或多个不同的β亚基组成,中央是具高度选择性只允许钠离子通过的亲水通道。电压门控钠离子通道在调节细胞膜电位、维持细胞离子稳态、细胞增殖和凋亡等生理过程中发挥着重要作用,因而钠离子通道自身的异变或是相关基因的变异都可能引起一系列身体病变。本文主要介绍了电压门控钠离子通道的结构与功能,阐述了其与癌细胞侵袭转移和神经病理性疼痛的关系,并介绍了几种典型的由钠离子通道基因变异引起的疾病。随着对电压门控钠离子通道及其异常分子机制研究的不断深入,新成果将为生理学、药理学和病理学等领域的研究提供理论基础和新的研究思路,为离子通道疾病的临床预防、诊断与治疗找到新途径。Voltage-gated sodium channels（VGSCs） of cell membrane, key molecules mediating the rising phase of the action potential, are composed of a large α-subunit and one or several different β-subunits. The centre is highly selectively hydrophilic that sodium ions are partly permeable. In recent years, Voltage-gated sodium channels have been reported playing an important role in the cell membrane potential, maintaining cell ion steady state and cell proliferation and apoptosis in different cell types, and they are closely related to cancer cells micrometastasis and neuropathic pain. This article analyzed the molecule structure and function of voltage-gated sodium channels, expounded the relationship between the sodium channels and the micrometastasis of cancer cells and neuropathic pain,introduced the research of several common sodium channel diseases, and emphasized the influence of the anomaly to human health.Along with the more in-depth study of the voltage-gated sodium channels, the molecular mechanism of abnormal ion channels will be clearer; meanwhile, it will provide a theoretical basis for the research of physiology, pharmacology and pathology, and explore new ways to cure the abnormality disease of ion channels.

关 键 词：电压门控钠离子通道 癌细胞转移 神经病理性疼痛 钠通道疾病 

分 类 号：R-1[医药卫生]