肺癌组织中SOX2和β-catenin蛋白的表达  

Expressions of SOX2 and β-catenin protein in lung cancer tissue

作　　者：谢爱民[1] 胡建明[1] 陈艰[1] 孙黄涛[1] 林庆[1] 陈美芳[1] 陈梅花[1] 

机构地区：[1]江西省人民医院心胸外科,南昌330000

出　　处：《郑州大学学报（医学版）》2014年第1期105-107,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨SOX2及Wnt/β-catenin信号通路与肺癌发生的关系。方法:收集86例肺癌组织和20例正常肺组织标本,应用免疫组化法检测SOX2、β-catenin蛋白的表达,分析SOX2、β-catenin蛋白在肺癌组织中表达的关联性。结果:SOX2在肺癌组织中的阳性表达率为95.4%,在正常肺组织中无表达;β-catenin在肺癌组织中的阳性表达率为75.6%,在正常肺组织中为30.0%;肺癌组织中两种蛋白的阳性表达率均高于正常肺组织(P<0.001)。二者在肺癌组织中的表达无关联(rP=0.109,P=0.978)。结论:SOX2和Wnt/β-catenin信号通路在肺癌的发生过程中发挥了重要作用。Aim：To investigate the expressions of stem cell factors SOX 2 and β-catenin in lung cancer tissue .Meth-o ds：A total of 86 cases of lung cancer tissue and 20 cases of normal lung tissue were collected and used to detect the expres -sions of SOX2 andβ-catenin by immunohistochemistry analysis .The correlation between SOX2 andβ-catenin expressions in lung cancer tissue was analyzed .Results：The positive expression rates of SOX 2 andβ-catenin were 95.4%and 75.6%in lung cancer tissue, significantly higher than those（0.0%and 30.0%） in normal lung tissue（P＆lt;0.001）.There was no posi-tive correlation between SOX2 and β-catenin expressions in lung cancer tissue （rP =0.109,P=0.978）.Conclusion：SOX2 and Wnt/β-catenin pathway may play important roles in occurrence of lung cancer .

关 键 词：肺癌 肿瘤干细胞 SOX2 WNT Β-CATENIN信号通路 SOX2 

分 类 号：R734.1[医药卫生—肿瘤]