老年高血压患者血管硬化与非酶糖基化及氧化应激的相关性研究  

Association of non-enzymatic glycosylation and oxidative stress with angiosclerosis in elderly hypertensive patients

作　　者：岳雅丽[1] 郭妍[1] 王俊宏[1] 方敏[1] 狄群[1] 

机构地区：[1]南京医科大学第一附属医院老年医学科,江苏省南京市210029

出　　处：《实用老年医学》2014年第1期33-36,共4页Practical Geriatrics

基　　金：江苏省自然科学基金(BK2011382)

摘　　要：目的探讨老年高血压患者血管硬化与非酶糖基化标志物羧甲基赖氨酸(carboxymethylysineadducts,CML)以及氧化应激指标过氧化物歧化酶(superoxide dismutase,SOD)、血清丙二醛(malondialdehyde,MDA)的相关性。方法对85例老年高血压住院患者采用全自动动脉硬化测量仪测定脉搏波传导速度(PWV),并采用ELISA法检测其血清CML、SOD及MDA水平。结果单因素分析显示PWV与年龄、CML与MDA呈正相关(P<0.05),CML与MDA呈正相关(P<0.01),与SOD呈负相关(P<0.01);多元回归分析结果显示PWV与年龄、CML及MDA呈正相关(P<0.05)。结论老年高血压患者血管硬化程度与非酶糖基化水平、氧化应激均呈正相关,非酶糖基化水平与氧化应激亦呈正相关。Objective To study the association of angiosclerosis with carboxymethyl （lysine）-adducts （CML）, superoxide dismutase（SOD） and malondialdehyde （MDA） in the elderly patients with essential hypertension. Methods Pulse wave velocity （PWV） was examined by auto-survey atherosclerosis apparatus ; serum levels of CML, SOD and MDA were measured by ELISA in 85 elderly hypertensive patients. Results Univariate analysis indicated PWV and age, CML and MDA were positively correlated （ P〈0. 05） , MDA and CML was significantly positively correlated （P〈0. 01 ）, SOD and CML was significantly negatively correlated （P〈0. 01） ; multiple regression analysis showed that PWV and age, CML and MDA were positively correlated （P〈0. 05）. Conclusions The degree of vascular sclerosis and non-enzymatic glycosylation, oxidative stress are positively correlated in the elderly patients with hypertension, and the level of non-enzymatic glycosylation is also positively correlated with oxidative stress.

关 键 词：脉搏波传导速度 血管硬化 氧化应激 非酶糖基化 

分 类 号：R541.3[医药卫生—心血管疾病]