DNMT3a基因突变与成人原发急性髓系白血病患者初诊时外周血象水平关系的Meta分析  

Correlation between DNMT3a Mutation and Peripheral Blood Cell Count in Adult Primary Acute Myeloid Leukemia: A Meta-Analysis

作　　者：沈克锋[1] 阴常欣[1] 叶艳艳[1] 江千里[1] 袁乐中 陆洋[2] 

机构地区：[1]南方医科大学南方医院血液科,广州510515 [2]南方医科大学第一临床学院,广州510515

出　　处：《中国循证医学杂志》2014年第2期225-230,共6页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金面上项目(编号:30901367)

摘　　要：目的系统评价DNMT3a基因突变与成人原发急性髓系白血病(AML)患者初诊时外周血象水平的关系。方法计算机检索PubMed、ScienceDirect、EBSCO、Web of Science、CNKI、VIP和WanFang Data数据库,纳入国内外公开发表的研究DNMT3a与成人原发AML患者初诊时外周血象水平相关性的病例-对照研究,检索年限均为从建库至2012年12月30日。由2位研究者根据纳入与排除标准独立筛选文献、提取资料并评价质量后,采用RevMan 5.2软件进行Meta分析。结果共纳入10个研究,合计2704例患者。Meta分析结果显示:成人原发AML患者DNMT3a突变组初诊时的外周血WBC、HGB、PLT数值均较DNMT3a未突变组高,差异均有统计学意义(P均<0.05)。结论成人原发AML患者中DNMT3a突变组初诊时的外周血象水平较DNMT3a未突变组高,这有助于我们更好地理解DNMT3a基因在AML发生发展中的作用。Objective To systematically review the correlation between DNMT3a mutation and peripheral blood cell count on the time of diagnosis for adult primary acute myeloid leukemia （AML）. Methods Literature search in the databases such as PubMed, ScienceDirect, EBSCO, Web of Science, CNKI, VIP and WanFang Data was performed to col- lect the case-control studies about the correlation between the DNMT3a mutations and adult AML up to December 2012. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data, and assessed the methodological quality of the included studies, and then RevMan 5.0 software was conducting for meta- analysis. Results A total of 10 studies involving 2 704 patients were included. The results of meta-analyses showed that： the levels of peripheral blood WBC, HGB and PLT of the DNMT3a-mutated group were significantly higher than those of the DNMT3a-wildtype group for the initial visit of adult primary AML patients （all P values 〈0.05）. Conclusion The peripheral blood cell counts of the DNMT3a-mutated group are higher than those of the DNMT3a-wildtype group for the initial visit of adult primary AML patients, indicating DNMT3a mutation might contribute to promote cell proliferation, and this helps us better understand the role of DNMT3a mutation in the development of AML.

关 键 词：DNMT3a基因突变 成人原发急性髓系白血病 外周血象 META分析 病例一对照研究 

分 类 号：R733.71[医药卫生—肿瘤]