E-钙粘蛋白、表皮生长因子受体、基质金属蛋白酶9表达与鼻咽癌预后的关系  

Study on the Relationship between Expression of E-cad、EGFR and MMP-9 and Metastasission in nasopharyngeal carcinoma

作　　者：杜心佳[1] 夏继云[1] 邱芳[1] 潘昌波 高永[1] 朱虹[1] 

机构地区：[1]山东省高密市人民医院,山东高密261500

出　　处：《中国处方药》2014年第1期42-44,共3页Journal of China Prescription Drug

摘　　要：目的检测并探讨鼻咽癌组织中E-钙粘蛋白(E-cadherin,E-cad)、表皮生长因子受体(Epidermal Growth Factor Receptor,EGFR)和基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)的表达与侵袭转移、预后的关系。方法选取62例鼻咽癌标本及45例癌旁组织标本,采用免疫组织化学染色方法(S-P法)检测鼻咽癌和癌旁组织中E-cad、EGFR、MMP-9的表达,并对所选病例进行随访。结果鼻咽癌组织中E-cad表达异常、EGFR及MMP-9的阳性表达率均高于癌旁组织,差异具有统计学意义(P<0.05),且三者的表达率与临床分期、有无淋巴结转移有关(P<0.05),与年龄、性别无关(P>0.05)。结论检测鼻咽癌患者E-cad、EGFR、MMP-9的表达情况对判断其恶性程度及预后有重要意义。Objective To study clinical relationship between the expression of E-cadherin（E-cad）、epidermal growth factor receptor （EGFR）、matrix metalloproteinase-9（MMP9）and Prognosis of nasopharyngeal carcinoma. Methods Immuno-histochemical method（S-P） was used to detect the expression of the E-cad、EGFR、MMP-9 in 62 cases of nasopharyngeal carcinoma and 45 cases of Nasopharyngeal normal tissues next to nasopharyngeal carcinoma. Results The positive expression rates of EGFR、MMP-9 and the abnormal expression rates of E-cad in the nasopharyngeal carcinoma were higher than those in the para-carcinoma tissues（P 〈 0.05）. Significant differences were found between the expression of the E-cad、EGFR and MMP-9 in nasopharyngeal carcinoma and clinical stage、lymph node metastasis（P 〈 0.05）.There was no significant correlation between E-cad、EGFR or MMP-9 expression and gender or age（ P〉0.05）. Conclusion There was significantly important to detect the expression of the E-cad、EGFR and MMP-9, which could forecast the degree of malignancy and prognosis of nasopharyngeal carcinoma .

关 键 词：鼻咽癌 免疫组化 上皮型钙粘附蛋白 表皮生长因子受体 基质金属蛋白酶9 

分 类 号：R739.63[医药卫生—肿瘤]