乳腺癌组织中乳腺癌易感基因1、增殖细胞核抗原Ki-67表达的临床意义  

Clinical significance of BRCA1 and Ki-67 expression in breast cancer

作　　者：吴晶晶[1] 陈曦[2] 陈雄[2] 欧阳学农[2] 吴晓龙[1] 张妍[3] 

机构地区：[1]福建中医药大学第二临床医学院,福州350122 [2]南京军区福州总医院肿瘤科 [3]福建医科大学福州总临床医学院

出　　处：《肿瘤研究与临床》2014年第1期1-5,共5页Cancer Research and Clinic

基　　金：福建省自然科学基金（2009J01185）

摘　　要：目的 探讨乳腺癌组织中乳腺癌易感基因1（BRCA1）、增殖细胞核抗原Ki-67表达的临床意义.方法 采用免疫组织化学法检测194例乳腺癌病理组织标本BRCA1、Ki-67的表达情况,并对其与临床病理参数的相关性进行分析.结果 194例乳腺癌中,淋巴结阳性组、雌激素受体（ER）/孕激素受体（PR）阴性组和人表皮生长因子受体2（HER-2）阳性组的BRCA1低表达率较高（P＜0.05）,三阴组中BRCA1低表达率高于非三阴组（P＜0.05）;Ki-67高表达者多为组织分级较高、ER/PR阴性和HER-2阳性患者（P＜0.05）;且BRCA1和Ki-67具有负相关性（P＜0.05）,绝经后、组织分级低、淋巴结阳性、ER/PR阴性、HER-2阳性患者的BRCA1低表达合并Ki-67高表达所占比例较高（P＜0.05）,但在三阴组与非三阴组间差异无统计学意义.结论 联合检测BRCA1、Ki-67对乳腺癌的临床转归具有一定预测意义,尤其是BRCA1可作为三阴性乳腺癌的预后因素之一.Objective To investigate the clinicopathologic features and prognostic significance of BRCA1 and Ki-67 expression in breast cancer. Methods The expression levels of BRCA1 and Ki-67 were assayed by immunohistochemistry in 194 cases of breast cancer tissues. The correlations of BRCA1 and Ki-67 expression with patients＂ clinicopathologie features were also analysed. Results Low expression of BRCA1 was detected in the lymph node metastasis group, ER/PR negative group, and HER-2 positive group in 194 patients with breast cancer （P 〈 0.05）, as well as in the triple negative breast cancer （TNBC） group compared to non-TNBC group （P 〈0.05）. High expression of Ki-67 was detected in patients with higher histological grade, negative ER/PR, and positive HER-2 （P 〈 0.05）. Furthermore, negative correlation was found between the expression of BRCA1 and Ki-67 （P 〈 0.05）. The combination of low expression of BRCA! and high expression of Ki-67 was mostly found in the patients with postmenopausal, lower histological grade, lymph node metastasis, negative ER/PR and positive HER-2 （P 〈 0.05）. However, there was no significant difference between TNBC and non-TNBC. Conclusion Joint detection of BRCA1 and Ki-67 might play an important role in predicting clinical outcomes of breast cancer, especially BRCA1 may be one of prognostic factors in TNBC.

关 键 词：乳腺肿瘤 乳腺癌易感基因1 KI-67 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]