凋亡抑制蛋白Survivin和缺氧诱导因子-1α在前列腺癌中的表达及其相关性  

Expression of Survivin and hypoxia inducible factor-1α in prostatic carcinoma and their correlations

作　　者：刘杰文[1] 路喜安[2] 郝利芬 齐广强[2] 雷杨[4] 

机构地区：[1]深圳市罗湖区人民医院病理科,518001 [2]山西医科大学第一医院病理科 [3]山西省中西医结合医院病理科 [4]山西省儿童医院病理科

出　　处：《肿瘤研究与临床》2014年第1期36-38,41,共4页Cancer Research and Clinic

摘　　要：目的 检测凋亡抑制蛋白Survivin、缺氧诱导因子-1α（HIF-1α）在前列腺增生和前列腺癌组织中的表达,探讨二者在前列腺癌发生、发展中的作用及相互关系.方法 免疫组织化学SP法检测Survivin、HIF-1 α在前列腺增生（15例）和前列腺癌（62例）组织中的表达,分析Survivin、HIF-1 α与前列腺癌临床病理特征的关系及二者之间的关系.结果 Survivin、HIF-1 α在62例前列腺癌组织中的阳性表达分别为44例（71.0％）、43例（69.4％）,在15例前列腺增生组织中的阳性表达分别为1例（6.7％）、0,两组差异均有统计学意义（x2值分别为20.56、23.56,均P=0.001）;Survivin和HIF-1α在前列腺癌组织中表达的阳性率与前列腺癌的组织学分级、临床分期有关（x2值分别为10.64、5.39、7.62、6.43,均P＜0.05）,二者表达呈正相关（rs=0.350,P=0.006）.结论 Survivin与HIF-1 α在前列腺癌发生、发展中起重要作用,两者之间存在协同作用.[Abstract] Objective To detect the expression of Survivin and hypoxia inducible factor-let （HIF-let） in prostatic hyperplasia and prostatic carcinoma, and investigate their roles and mutual correlations in pathogenesis and progression of prostatic carcinoma. Methods The expression of Survivin and HIF-1α in proliferative lesions of prostate （15 cases） and prostatic carcinoma （62 cases） were detected by immunohistochemistry method. The relationship between the expressions of Survivin and HIF-1α was analyzed, as well as their correlations with clinicopathological features. Results The positive expression of Survivin and HIF-1α were significantly higher in the prostatic carcinoma [71.0 % （44/62） and 69.4 % （43/62）, respectively] compared with those of the prostatic proliferation [6.7 CTv （1/15） and 0] （X2 = 20.56, P = 0.001; X2 = 23.56, P = 0.001, respectively）. The expression of Survivin and HIF--1α in prostate carcinoma was significantly related with the histological grading, clinical staging （X2= 10.64, 5.39, 7.62, 6.43, all P 〈 0.05）. And there was positively correlated between Survivin and HIF-1α（rs= 0.350, P = 0.006）. Conclusion Survivin and HIF-1αsynergistically play important roles in pathogenesis and progression of prostatic carcinoma.

关 键 词：前列腺肿瘤 SURVIVIN 缺氧诱导因子-1Α 

分 类 号：R737.25[医药卫生—肿瘤]