人类免疫缺陷病毒感染合并急性早幼粒细胞白血病及慢性粒细胞白血病二例并文献复习  

Human immunodeficiency virus infection concurrent with acute promyelocytic leukemia and chronic myeloid leukemia： two cases report and literatures review

作　　者：周云[1] 何传俊[1] 吴春龙[1] 谢晓英[1] 马丽[1] 

机构地区：[1]四川省凉山彝族自治州第一人民医院血液科,西昌615000

出　　处：《白血病．淋巴瘤》2014年第1期45-47,52,共4页Journal of Leukemia & Lymphoma

摘　　要：目的 探讨人类免疫缺陷病毒（HIV）感染患者合并急性早幼粒细胞白血病（APL）及慢性粒细胞白血病（CML）的临床特点、有效的治疗方案及预后.方法 回顾性分析1例HIV感染合并APL及1例HIV感染合并CML患者临床资料,并复习文献.结果 1例患者为26岁男性,彝族,同时诊断HIV感染合并APL,采用亚砷酸诱导缓解治疗,在治疗第8天因脑功能障碍死亡.另一例患者为45岁男性,汉族,同时诊断HIV感染合并CML,采用羟基脲及干扰素治疗,3个月后病情进展至急变期,进行联合化疗后病情进行性加重,后期死于肺部多重感染（真菌合并卡氏肺囊虫）、呼吸衰竭.结论 HIV感染合并急、慢性白血病患者治疗效果较差,并发感染重.Objective To study the clinicopathologic features,effective therapeutic regimen and prognosis of human immunodeficiency virus （HIV） infection with acute promyelocytic leukemia （APL） and chronic myeloid leukemia （CML）.Methods Two cases of HIV infection concurrent with leukemia,one with APL,one with CML,were studied and relevant literatures were reviewed.Results Case 1 was HIV infection concurrent with APL,ATO was used to induce remission,in the eight day of therapy,the patient died of brain disorder.Case 2 was HIV infection concurrent with CML,hydroxycarbamide and interferon were used to induce remission,three month later,state of an illness progressed to acute phase,after combination chemotherapy,concurrent with lung multiple infection （fungus and pneumocystis carinii）,at last,the patient died of respiratory failure.Conclusion HIV infection concurrent with acute and chronic leukemia has poor therapeutic effect,and is easy to infect seriously.

关 键 词：人免疫缺陷病毒 白血病 早幼粒细胞 急性 白血病 髓系 慢性 

分 类 号：R733.71[医药卫生—肿瘤]