乌司他丁治疗急性胰腺炎临床疗效观察  

Clinical observation on Ulinastatin in treating acute pancreatitis

作　　者：黄宗文[1] 于迎春[1] 张颖[1] 杨晓楠[1] 夏庆[1] 

机构地区：[1]华西医科大学附属第一医院,成都610041

出　　处：《临床外科杂志》2001年第1期33-36,共4页Journal of Clinical Surgery

摘　　要：目的　观察乌司他丁治疗急性胰腺炎的临床疗效。方法　将 110例急性胰腺炎随机分成两组 ,对照组 5 5例 (轻症 40例、重症Ⅰ型 15例 ) ,治疗组 5 5例 (轻症 40例、重症Ⅰ型 15例 )。对照组采用常规中西医结合治疗 ,治疗组采用常规中西医结合治疗加乌司他丁 10万单位溶于 5 0 0ml 5 %葡萄糖注射液中静脉滴注 ,每天 2次 ,轻症用 7d ,重症Ⅰ型用 14d。结果　治疗组有效率轻症为 92 .5 % ,重症Ⅰ型为 86 .7% ,与对照组有效率轻症为 72 .5 % ,重症Ⅰ型为 40 .0 % ,两组比较差异有显著性 ;早期使用乌司他丁治疗后腹部症状、体征较快缓解 ,血尿淀粉酶、TB、DB、ALT、LDH、AST迅速下降 ,与对照组比较也有差异。结论　早期使用乌司他丁对急性胰腺炎有明显抑制作用 ,无明显毒副作用 ,可作为急性胰腺炎综合治疗的组成部分之一。Objective To observate clinical effects of Ulinastatin(UTI) on treating acute pancreatitis.Methods 110 patients with acute pancreatitis were randomly divided into two groups. There were 55 cases (40 cases of light type, 15 cases of severe typeⅠ ) in control group, which were treated with integrated traditional and western medicine (ITWM). There were 55 cases (40 cases of light type, 15 cases of severe typeⅠ ) in treatment group, which were treated with ITWM and UTI 10000u + 5% glucose injection 500ml two times a day. Time of treatment was 7 days in light type,14 days in severe typeⅠ.Results The effective rate was 92.5% in light type, 86.7% in severe typeⅠ in treatment group ,while the effeative rate was 72.5% in light type, 40.0% in severe typeⅠ in control group. After treatment with UTI, abdominal symptoms and signs disappeared rapidly, serum and urinary amylase,TB,DB,ALT,LDH and AST were declined in treatment group,which were statistically different as compared with control group.Conclusions UTI can evidently inhibit acute pancreatitis in early stage without apparent side effects, UTI may be regard as one of the of comprehensive treatments for acute pancreatitis.

关 键 词：急性胰腺炎 乌司他丁 中西医结合治疗 

分 类 号：R576.05[医药卫生—消化系统]