巨噬细胞抑制因子1在消化道肿瘤中的研究进展  

Research Progress of MIC-1 in the Digestive Tract Tumor

作　　者：李倩[1] 侯亚平[1] 

机构地区：[1]湖南省马王堆医院中医科,长沙410016

出　　处：《医学综述》2014年第3期432-434,共3页Medical Recapitulate

基　　金：湖南省科技计划项目(2009sk3068)

摘　　要：巨噬细胞抑制因子1(MIC-1)是人转化生长因子超家族中的一员。近年来研究表明,MIC-1与肿瘤的发生、发展密切相关,并可能具有促瘤与抑瘤的双重作用。MIC-1在多种消化道肿瘤的血清或肿瘤组织中呈高表达,并与肿瘤的临床分期、浸润程度具有明显相关性,同时它对多种消化道肿瘤有良好的早期诊断价值,表现出较高的敏感性和特异性。Abstraet：Macrophage inhibitory cytokine-1 （ MIC-1 ） is a member of the transforming growth factor superfamily. Recent studies indicated that MIC-1 is closely related with the occurrence and development of tumors,possible with the dual function of tumor protnoting and suppressing. MIC-1 is highly expressed in a variety of serum or tumor tissues of digestive tract tumors,which is significant associated with clinical stages and infiltration of the cancer. MIC-I has a good value for the early diagnosis of a variety of digestive tract tumors, with high sensitivity and specificity. Key words： Macrophage inhibitory cytokine-1 ; Gastrointestinal tumors ; Clinical stage ; Sensitivity ; Specificity

关 键 词：巨噬细胞抑制因子1 消化道肿瘤 临床分期 敏感性 特异性 

分 类 号：R735[医药卫生—肿瘤]