自体CIK回输对转移性恶性肿瘤细胞免疫指标变化的影响  

Effects of autologous CIK cell therapy on cellular immunity in malignant tumor

作　　者：和钢[1] 杨峂[1] 张顺[2] 

机构地区：[1]宁波市第二医院肿瘤外科,浙江宁波315010 [2]宁波市第二医院临床检验中心,浙江宁波315010

出　　处：《实用肿瘤杂志》2014年第1期45-48,共4页Journal of Practical Oncology

摘　　要：目的探讨CIK治疗前后不同时间点T细胞亚群变化对恶性肿瘤临床疗效的影响。方法采用流式细胞术对71例恶性肿瘤患者外周血T细胞亚群进行检测。结果与非转移组比较,转移组T淋巴细胞亚群绝对数值增高(P<0.01),乳腺癌肺转移(15例)Th、NK指标高于均值(35.67±5.28和25.62±7.24),增幅比率41.6%(15/36),CD4+/CD8+绝对值增幅>45%(由0.8±0.3到1.7±0.6;P<0.01)。转移组总有效率52.8%,非转移组总有效率91.4%。结论 CIK治疗对肿瘤负荷的缓解作用和提高疗效方面具有一定的临床意义。Objective To explore the change of T cell subsets before and after CIK cell therapy at different time points in patients with advanced malignant tumor and its clinical effects. Methods The T cell subsets before and after CIK cell therapy of 71 patients with malignant tumors were detected by flow cytometry. Results The absolute value of T cell subsets in metastatic group was significantly higher than that of non-metastatic group（P 〈 0.01 ）. The Th and NK indexes in 15 cases of breast cancer with lung metastasis were significantly higher than mean index （35.67± 5.28 and 25.62 ± 7.24 ）, the increase rate was 41.6% （15/36） and the CD4 ＋/CD8 ＋ absolute increased more than 45% （from 0.8±0.3 to 1.7 ± 0.6 ;P 〈0.01 ）. The total response rates were 52.8% and 91.4% in metastatic and non-metastatic groups, respectively. Conclusion Autologous CIK cell therapy has clinical significance for reducing tumor burden and improving clinical effects for malignant tumor.

关 键 词：肿瘤 CIK细胞 免疫疗法 流式细胞术 T淋巴细胞亚群 

分 类 号：R730.5[医药卫生—肿瘤]