干扰素α联合治疗晚期结直肠癌的Meta分析  

Adjuvant Therapy with Interferon-alpha for Patients with Advanced Colorectal Cancer: A Meta-analysis

作　　者：马新福[1] 王晓龙[1] 张成武[1] 赵久达[2] 文英[1] 

机构地区：[1]青海大学医学院附属医院胃肠外科,青海省西宁市810000 [2]青海大学医学院附属医院肿瘤内科,青海省西宁市810000

出　　处：《中国全科医学》2014年第3期304-307,313,共5页Chinese General Practice

摘　　要：目的用Meta分析的方法定量评价干扰素α(IFN-α)联合治疗晚期结直肠癌的效果。方法计算机检索Cochrane Library(2012年第2期)、PubMed(1966年1月—2012年8月)、Embase(1974年1月—2012年8月)、中国生物医学文献数据库(1978年1月—2010年8月)、中文科技期刊全文数据库(1989年1月—2012年8月)、中国期刊全文数据库(1994年1月—2012年8月)关于IFN-α联合化疗治疗晚期结直肠癌的随机对照试验,其中试验组采用IFN-α联合常规化疗,对照组采用常规化疗。由两名评价者单独评价纳入研究的方法学质量并提取资料,用RevMan 5.1软件进行Meta分析。结果共纳入10项研究,共计1 625例患者,其中试验组784例,对照组841例。Meta分析结果显示:试验组治疗后有效率〔OR=1.03,95%CI(0.74,1.43)〕和总生存期〔HR=0.97,95%CI(0.86,1.10)〕与对照组比较,差异均无统计学意义。结论与常规化疗相比,IFN-α联合化疗治疗并不能提高晚期结直肠癌患者的有效率,也不能使患者生存受益。但上述结论尚待大样本、高质量的随机对照试验进一步证实。Objective To quantitatively assess the efficacy of interferon - alpha （ IFN - ct） in the adjuvant treatment of advanced eolorectal cancer by using Meta - analysis. Methods We searched the Cochrane Library （ the second issue of 2012）, PubMed （from January 1966 to August 2012）, Embase （from January 1974 to August 2012）, Chinese Biomedicine Literature Database （from January 1978 to August 2010） , Chinese Scientific Journals Full - text Database （from January 1989 to August 2012） and Chinese Journal Full -text Database （from January 1994 to August 2012 ） for randomized controlled trials regarding IFN - ot in the treatment of advanced colorectal cancer. IFN - α and routine chemotherapy were used in the experiment group and only routine chemotherapy was used in the control group. Two reviewers independently assessed the quality of included studies and extracted data. We analyzed the data by using RevMan 5.1. Results Ten randomized controlled trials totaling 1 625 patients were included, 784 in the experiment group and 841 in the control group. Meta analysis indicated that no significant difference was found in overall response rate [ OR = 1.03, 95 % CI （0. 74, 1.43 ） ] and overall survival [ HR = 0. 97, 95% CI （ 0. 86, 1.10） ] between the experiment group and the control group. Conclusion Compared with chemotherapy alone, IFN - α plus chemotherapy has no beneficial effect on survival rate, but the results still need to be confirmed by high quality and large sample size randomized controlled trials.

关 键 词：结直肠肿瘤 干扰素Α 抗肿瘤联合化疗方案 META分析 

分 类 号：R735.34[医药卫生—肿瘤]