纳米碳吸附5-氟尿嘧啶在大肠癌淋巴化疗中的临床研究  

The clinical application of nano-carbon loaded 5 Fluorouracil in the colorectal cancer of lymphatic chemotherapy

作　　者：矫树华[1] 刘鹏亮[1] 史继伟[1] 温艳惠[1] 

机构地区：[1]中国医科大学附属第四医院消化科,辽宁沈阳110005

出　　处：《东南国防医药》2014年第1期18-19,39,共3页Military Medical Journal of Southeast China

基　　金：辽宁省科技厅科学技术研究项目(2010225032);辽宁省教育厅科学技术研究项目(L2010680)

摘　　要：目的探讨纳米碳吸附5-氟尿嘧啶(5-Fu)在大肠癌淋巴化疗中的应用。方法将58例大肠癌随机分为两组,观察组30例和对照组28例。观察组在术前经肠镜在癌灶周围注射纳米碳5-Fu混合液,术中根据淋巴结黑染情况标记指导大肠癌根治术的淋巴结清扫,对照组不经处理;两组均行大肠癌根治及淋巴结清扫术。结果观察组术中可见淋巴结有不同程度的黑染,两组平均每例清除的淋巴结数量及清除转移淋巴结的坏死数量,观察组均显著高于对照组(P<0.05)。结论术前注射纳米碳5-Fu混悬液具有提高淋巴结清扫的数量和提高淋巴化疗功效的双重作用。Objective To investigate the tracing value of nano-carbon loaded 5-Fu for lymphatic visualization and its curative effect in the lymphatic chemotherapy of coloreetal cancer. Methods fifty-eight cases of coloreetal cancer were randomized into 2 groups： experimental group （n = 30）, control group （n = 28）. The experimental group injection the nano carbon 5-Fu mixture before the preoperative colonoscopy. According to the Intraoperative lymph blacking marker in colorectal cancer radical masteetomy guidance lymph node dissection, both groups underwent colorectal cancer and lymph node dissection. Results Various degrees of stained lymph nodes were seen in experimental group. The necrosis rates of eliminated lymph nodes in two groups were respectively, experimental group were significantly higher than control group （ P 〈 0. 05 ）. Conclusion Local injection nano carbon 5-Fu mixture around the tumor have both effects of guidance to lymph node dissection and lymphatic chemotherapy.

关 键 词：大肠癌 淋巴化疗 转移 纳米碳 

分 类 号：R735.34[医药卫生—肿瘤]