惠州地区胆管癌相关危险因子的医院人群病例对照研究  

Risk Factor Associated with Cholangiocarcinoma in Huizhou District: A Patients-based Case-control Study

作　　者：钟洪才[1,2] 罗云藩[2] 李胜新[1,2] 罗小平[2] 邓予[2] 胡斌 

机构地区：[1]广东省惠州市医学研究所,广东惠州516001 [2]广东省惠州市中心人民医院 [3]广东省惠州市博罗人民医院

出　　处：《中国医学创新》2014年第4期13-15,共3页Medical Innovation of China

基　　金：广东省惠州市科技基金资助项目(20110802)

摘　　要：目的：探讨惠州地区胆管癌发生的相关危险因子。方法：采用多中心的医院人群病例对照研究。病例组：收集惠州市中心人民医院及博罗县人民医院2007年1月-2012年12月106例胆管癌患者的临床资料。对照组：按照同性别、同民族、年龄相差±5岁。居住在惠州，1：1配比106例同期在以上两所医院住院的非肿瘤患者。统计两组的饮酒史、吸烟史、饮食习惯、高血压病、糖尿病、高脂血症、HBsAg（＋）、胆囊结石或胆囊切除病史、胆管结石等资料，并进行单因子及多因子Logistic分析。结果：病例组与对照组的饮食习惯差异有统计学意义（P〈0．05）a病例组高脂血症、HBsAg（＋）、胆管结石或胆囊切除史、胆管结石的发生率均高于对照组（P〈0．05）；高脂血症、胆管结石调整OR（95％CI）分别为12．8（5．3～30．6）、18.2（1．7～192．9）.结论：胆管结石、高脂血症是惠州地区胆管癌发生的危险因子。Objective： To explore the risk factors of cholangioearcinoma in Huizhou district. Method： One-hundred and six patients suffering eholangiocarcinoma matched by sex, nationality, age （＋/-5years）, hospital admittance and place of residence were interviewed in Huizhou district between 2007 and 2012, and their 9 information（ dietary habit, smoking, drinking, hypertension, diabetes, hyperlipemia, HBsAg （＋）, gallbladder stone or cholecystectomy, cholangiolithiasis ） were collected. Odds ratios （ OR ） and 95% confidence intervals （ CI ） were calculated for each risk factor. Result： Univariate analysis showed that the risk factors for development of cholangiocareinoma were hyperlipemia, HBsAg （ ＋ ）, gallbladder stone or choleeystectomy, cholangiolithiasis, and also showed that the factor for decrease in risk among individuals who consume more sea food （ P〈0.05 ） . In multivariate stepwise logistic regression analysis, hyperlipemia （ OR=12.8, 95%CI： 5.3-30.6 ） and cholangiolithiasis （ OR=18.2, 95% CI： 1.7-192.9 ） were independent factors （ P〈0.05 ） . Conclusion： This finding suggest that hyperlipemia and cholangiolithiasis are the risk factors for development of eholangiocarcinoma in Huizhou district.

关 键 词：胆管癌 危险因子 病例对照研究 

分 类 号：R735.8[医药卫生—肿瘤]