幽门螺杆菌感染对寻常痤疮的影响分析  

Influence of Helicobacterpyloriinfection on acne vulgaris

作　　者：马新华[1] 陈仕胜[1] 金宛宛[1] 

机构地区：[1]温州医科大学附属第二医院皮肤科,浙江温州325000

出　　处：《中华医院感染学杂志》2014年第4期924-925,958,共3页Chinese Journal of Nosocomiology

基　　金：浙江省科技厅基金资助项目(2012C30653)

摘　　要：目的探讨幽门螺杆菌感染对寻常痤疮发生的相关性,以及幽门螺杆菌根除对痤疮的影响,为临床治疗寻常痤疮寻找新的途径。方法选择2012年3月-2013年3月医院诊治的寻常痤疮Ⅰ、Ⅱ级患者共239例作为观察组,并按照有无合并胃部症状将其分为A组合并胃部症状102例和B组未合并胃部症状137例,再选取医院无痤疮和胃部症状的50名工作人员作为对照组,检测观察组和对照组的幽门螺杆菌感染情况;观察组中合并有幽门螺杆菌感染的患者采取幽门螺杆菌根治治疗方案,观察患者痤疮的改善。结果观察组中A组102例患者幽门螺杆菌感染88例,感染率为86.3%,B组137例患者幽门螺杆菌感染82例,感染率为59.9%,A、B两组患者感染率比较差异有统计学意义(χ2=19.875,P<0.01);观察组239例患者中幽门螺杆菌感染170例,感染率为71.1%,对照组50例中幽门螺杆菌感染23例,感染率为46.0%,观察组与对照组感染率比较差异有统计学意义(χ2=11.771,P<0.01);观察组中170例幽门螺杆菌感染患者采取抗幽门螺杆菌治疗,治疗后幽门螺杆菌根除148例,根除率为87.1%。结论幽门螺杆菌感染合并胃部症状与痤疮的发病之间存在一定的联系,且通过抗幽门螺杆菌治疗后,可以减轻患者的痤疮程度、减少病灶,为临床治疗顽固性的痤疮提供了新的思路。OBJECTIVE To explore the correlation between the Helicobacter pylori infection complicated stomach symptoms and the acne vulgaris and analyze the influence of eradication of H. pylori on acne so as to seek new approach for clinical treatment of acne vulgaris. METHODS Totally 239 patients with type I or II ache vulgaris, who were treated in the hospital from Mar 2012 to Mar 2013 were chosen as the observation group and divided into the group A （with gastric symptoms, 102 cases ） and the group B （ without gastric symptoms, 137 cases ） , while 50 medical staff without acne or gastric symptoms were set as the control group; the incidence of H. pylori infection was observed and compared between the observation group and the control group; the patients complicated with H. pylori infection in the observation group received the eradication of H. pylori, and the improvement of acne was observed. RESULTS The H. pylori infection occurred in 88 of 102 cases in the group A with the infection rate of 86. 3 and in 82 of 137 cases in the group B with the infection rate of 59.9, the difference in the infection rate between the two groups was statistically significant（z = 19. 875 ,P%0.01） ; the H. pylori infection occurred in 170 of 239 cases in the observation group with the infection rate of 71.1 and in 23 of 50 cases in the control group with the infection rate of 46.0K, the difference in the infection rate between the observation group and the control group was statistically significant （Zz = 11. 771, P0.01）. Among the 170 cases of H. pylori infections who received the treatment of H. pylori, the H. pylori has been eradicated in 148 cases with the eradication rate of 87. 1. CONCLUSION There is a certain correlation between the H. pylori infection complicated with gastric symptoms and the onset of acne. The treatment of H. pylori can reduce the degree of ache and decrease the lesions, which provides a new idea for the clinical treatment of intractable acne.

关 键 词：幽门螺杆菌 胃部症状 寻常痤疮 相关分析 

分 类 号：R573[医药卫生—消化系统]