影像引导放疗中交互式肿瘤靶区勾画方法  

Interactive Target Delineation in Clinical Treatment Planning of Image Guided Radiation Therapy

作　　者：周武[1] 谢耀钦[1] 田洋洋[1] 

机构地区：[1]中国科学院深圳先进技术研究院,深圳518055

出　　处：《集成技术》2014年第1期68-76,共9页Journal of Integration Technology

基　　金：中国博士后科学基金(2013M530740);国家自然科学基金(81171402);国家自然科学基金海外研究基金;港澳合作研究基金(30928030);国家重点基础研究发展计划973(2010CB732606);广东省创新团队项目(2011S013)

摘　　要：在图像引导放射治疗中肿瘤(靶区)和危险器官的勾画是制定放疗计划的重要环节。在临床应用中靶区勾画通常是由医生手动完成,虽然这种方法普遍被认为可靠,但是耗时较多且精度受医生主观影响较大。由于临床上人体组织结构的多样性和靶区目标影像的复杂性,自动勾画方法在精度和可靠性上并不能较好的满足实际临床需求。文章提出了一种交互式轮廓勾画的方法,结合自动的活动轮廓模型和手动交互的多尺度曲线编辑方法实现靶区的快速精确勾画。通过初始化轮廓调整使活动轮廓模型快速可靠地达到目标轮廓,然后使用多尺度数字曲线编辑可实现对复杂形状轮廓的快速修正。医学临床实验结果验证了方法的有效性。The accurate contour delineation of the target and organs at risk （OAR） is essential in treatment planning for image guided radiation therapy. In clinical applications, the contour delineation is often done manually by clinicians, which may be accurate, but time-consuming and tedious for users. Although a lot of automatic contour delineation approaches have been proposed, few of them can fulifll the necessities of applications in terms of accuracy and efifciency. In this work, a novel approach of target delineation was proposed. Target delineation of OARs was achieved by using snake model and multiscale curve editing to obtain promising results. It allows users to quickly improve contours by a simple mouse click. Experimental results demonstrate the effectiveness of the proposed method for clinical target delineations.

关 键 词：轮廓勾画 活动轮廓模型 曲线编辑 放疗计划 影像引导放疗 

分 类 号：R730.5[医药卫生—肿瘤] TP391.41[医药卫生—临床医学]