喉癌患者血清SIL-2R与预后的前瞻性研究  

A prospective study on relationship between serum SIL-2R levels and prognosis in laryngeal carcinoma

作　　者：马玲国[1] 刘学仁[2] 王天铎[1] 

机构地区：[1]山东医科大学第一临床医学院耳鼻咽喉科,济南250012 [2]山西医科大学第二临床医学院耳鼻咽喉科

出　　处：《山西医科大学学报》2001年第1期77-79,共3页Journal of Shanxi Medical University

摘　　要：目的　探讨SIL 2R与喉鳞癌的关系 ,评价血清SIL 2R水平检测对喉鳞癌预后的临床价值。方法　应用单克隆、多克隆双抗体夹心ELISA检测了 35例喉鳞癌患者的血清SIL 2R水平 ,对患者远期生存情况进行了随访和统计分析。结果　喉癌患者血清SIL 2R水平较良性组或正常人显著升高 (P <0 .0 0 1) ,与喉癌临床分期、T分级呈显著正相关 ,与临床分型及淋巴结转移亦密切相关 ;血清SIL 2R水平升高者 (>30 4.9kU/L)预后显著差于未升高者 (<30 4.9kU/L)。结论　血清SIL 2R水平不仅与喉癌的临床进程及生物学行为 (如淋巴结转移等 )有密切关系 。Objective To study the relationship between SIL 2R and laryngeal carcinoma and evaluate the clinical value of serum SIL 2R levels and prognosis in laryngeal carcinoma. Method The serum SIL 2R levels were measured with ELISA in 35 patients with laryngeal carcinoma,and the survival period of these followed up patients was statistically analyzed. Results The serum SIL 2R levels in patients with laryngeal carcinoma were significantly higher than in healthy subjects or in patients with laryngeal benign tumor( P <0.001),closely related to clinical staging,T classification,lymph node metastasis as well as original site of laryngeal carcinoma.The survival period of patients with higher SIL 2R levels(>304.9 kU/L) was significantly shorter than that of patients with lower SIL 2R levels(<304.9 kU/L). Conclusion Serum SIL 2R levels not only closely relate to clinical development and biological behavior of laryngeal carcinoma,but also can serve as an assistant index in predicting prognosis of laryngeal carcinoma.

关 键 词：喉肿瘤 预后 喉癌 SIL-2R 前瞻性研究 

分 类 号：R739.65[医药卫生—肿瘤] R730.7[医药卫生—临床医学]