血尿酸水平对急性缺血性卒中患者血管再通和梗死体积的影响  

Influence of blood uric acid levels on the recanalization and infarct volume in patients with acute ischemic stroke

作　　者：王运良[1] 曾志磊[2] 张晓席[1] 尹红蕾[1] 李金凤[1] 耿爽[1] 

机构地区：[1]解放军148医院神经内科,山东淄博255300 [2]郑州大学第二附属医院神经内科,河南郑州450014

出　　处：《实用医药杂志》2014年第1期3-5,共3页Practical Journal of Medicine & Pharmacy

摘　　要：目的探讨急性缺血性卒中患者血尿酸(UA)浓度的变化对血管再通和梗死体积的影响。方法对176例发病24 h内患者,应用弥散加权核磁共振(DWI)检查,证实为前循环急性缺血性卒中。经改良的NIH卒中(mNIHSS)评分5分以上,随访观察血尿酸、尿囊素(尿酸的非酶代谢产物)浓度变化对血管再通和梗死体积的影响。结果 66例血管再通患者多数接受溶栓治疗,UA浓度在48 h降低,然后逐渐升高呈U行改变,14 d时mNIHSS评分降低,UA和尿囊素浓度变化与DWI梗死体积明显相关。结论 UA是急性缺血性卒中的一种消耗和再生性抗氧化剂,其浓度的变化与血管再通和梗死体积有关。Objective To explore the influence of uric acid concentration changes on the recanalization and infarct volume in patients with acute isehemic stroke. Methods The 176 patients within 24 hours of symptom onset, were examined with diffusion weighted magnetic resonance imaging （DWI） and confirmed as the acute ischemic stroke in the anterior circulation system, whom a modified NIH Stroke Scale（mNIHSS） score was 5or greater, and followed -up for the influence of uric acid（UA） and allantion（ a nonenzymatic metabolite of UA） levels on recanalization and DWI infarction volume. Results The 66 patients with recanalized vessels had mostly received thrombolytic therapy,the UA levels dropped at 48 hours and then gradually increased in a U -shaped pattern. At dayl4 mNIHSS scores reducted, UA and allantoin concentration with DWI in- farction volume there was significant relativity. Conclusion UA might be a kind of consumption and regeneration antioxida- nts in acute ischemic stroke, and its concentration changes are related with recanalization and infarction volume.

关 键 词：尿酸 急性缺血性卒中 血管再通 神经保护 

分 类 号：R743.3[医药卫生—神经病学与精神病学]