T2期直肠癌淋巴结转移情况的临床病理因素分析  

Clinicopathologic Factors of Lymph Node Metastasis in T2 Rectal Cancer

作　　者：张晓路[1] 王鑫[1] 徐岩[1] 孙哲[1] 鲁翀[1] 王振宁[1] 邢承忠[1] 

机构地区：[1]中国医科大学附属第一医院肿瘤外科,沈阳110001

出　　处：《中国医科大学学报》2014年第2期142-145,共4页Journal of China Medical University

基　　金：辽宁省科学技术计划(2012225016)

摘　　要：目的探讨与T2期直肠癌淋巴结转移密切相关的临床病理因素。方法收集1999年11月至2012年7月经中国医科大学附属第一医院肿瘤外科诊断明确并施行根治性手术的T2期直肠癌320例，回顾性分析其各临床病理因素与淋巴结转移之间的关系。结果单因素及多因素分析结果显示：淋巴管血管浸润（P=0．000，OR=10．004，95％CI：2．855～35．065）、组织学类型（P=0．006，OR=1．518，95％CI：1．124～2．049）和浸润深度（P=0．039，OR=2．097，95％CI：1．038～4．237）是淋巴结转移独立危险因素。本组淋巴结转移率为20．6％，浸润浅肌层和深肌层者淋巴结转移率分别为12．2％和24.3％。结论淋巴管血管浸润、组织学类型和浸润深度对T2期直肠癌淋巴结转移影响较大。Objective To study the risk factors associated with lymphatic metastasis of T2 rectal cancer. Methods A total of 320 patients with T2 rectal cancer who underwent curative resection in our hospital from Nov 1999 to Aug 2012 were collected. The relationship between its clinicopatho- logic factors and lymph node metastasis （LNM） was analyzed retrospectively. Results Single factor and multifactor Logistic regression analysis demonstrated that the lymphatic and venous invasion （ P = 0.000, OR =10.004,95%CI ： 2.855-35.065 ）, histological type （ P = 0.006, OR =1.518, 95%CI ： 1.124-2.049 ） and depth of tumor invasion （ P = 0.039, OR =2.097,95%CI ： 1.038-4.237 ） were the major factors in T2 colorectal carcinoma of LNM. The rate of LNM was 20.6% in this case, 12.2% in patients with shallow muscularis propria involvement, and 24.3% in those with deeper muscular layer involvement. Conclusion The lymphatic and venous invasion, histological type and depth of tumor invasion are the major relevant factors of LNM in T2 rectal cancer.

关 键 词：直肠肿瘤 T2期 淋巴结转移 局部切除 

分 类 号：R735.37[医药卫生—肿瘤]