液固压缩技术对α-细辛脑溶出的影响  

Effects of Liquisolid Compression Technology on the Dissolution of α-Asarone

作　　者：赵许杰[1,2] 闫雪生[1] 

机构地区：[1]山东省中医药研究院,济南250014 [2]山东中医药大学药学院,济南250355

出　　处：《中国药房》2014年第7期620-622,共3页China Pharmacy

摘　　要：目的:探讨液固压缩技术对α-细辛脑溶出的影响。方法:采用液固压缩技术制备α-细辛脑液固压缩片(液体赋形剂为吐温80或聚乙二醇400,载体材料为PH-101微晶纤维素,涂层材料为微粉硅胶200),与市售细辛脑片在片剂质量和溶出度方面进行比较。结果:α-细辛脑液固压缩片中α-细辛脑在短时间内迅速溶出,5 min时达到80%以上,是市售细辛脑片溶出度的3倍,且崩解时限均<100 s。结论:液固压缩技术对难溶性药物α-细辛脑的溶出有一定帮助。OBJECTIVE： To study the effects of liquisolid compression technology on the preparation of α-Asarone. METHODS： α-Asarone liquisolid compressed tablets were prepared by liquisolid compression technology using tween80 or polyethylene glycol 400, PH 101 avicel and aerosil200 as drug-excipients, carrier and coating material, respectively. It was compared with mar- keted tablets in terms of the quality of tablet and the dissolution. RESULTS： In the liquisolid compressed tablet, α-Asarone were rapidly dissolved; 80% tablet was released within 5 minutes,which was 3 times higher than the tablet on the market. And the disintegration time was less than 100 s. CONCLUSIONS： The liquisolid compression technology has some advantages in the dissolution of insoluble α-Asarone.

关 键 词：Α-细辛脑 吐温80 聚乙二醇400 液固压缩片 崩解时限 溶出度 

分 类 号：R284.2[医药卫生—中药学] R283[医药卫生—中医学]