斑蝥酸钠维生素B6注射液辅助治疗肝癌随机对照的Meta分析  

Adjuvant treatment with disodium cantharidinate and vitamin B6 injection for patients with hepatocellular carcinoma： a Meta analysis based on randomized controlled trials

作　　者：汪晓凤[1] 罗新华[1] 

机构地区：[1]贵州省人民医院感染病科,贵阳550002

出　　处：《国际肿瘤学杂志》2014年第1期69-73,共5页Journal of International Oncology

摘　　要：目的 评价斑蝥酸钠维生素B6注射液辅助治疗肝癌患者的有效性与安全性.方法 计算机检索EMbase、PubMed、Cochrane图书馆、中国生物医学文献数据库、维普数据检索平台、中国知网数据检索平台和万方数据检索平台有关斑蝥酸钠维生素B6注射液辅助治疗肝癌的相关文献.用Cochrane协作网提供的RevMan 5.0软件进行Meta分析.结果 纳入4篇随机对照试验文献,共计307例患者.结果显示,斑蝥酸钠维生素B6注射液辅助治疗组与对照组相比可提高近期疗效（RR=1.40,95％ CI为1.04 ～1.89,P=0.03）和改善生活质量（RR =1.67,95％ CI为1.28 ～ 2.17,P=0.000 1）.此外,还可减轻胃肠道反应（RR =0.62,95％ CI为0.42 ～0.93,P=0.02）,减少骨髓抑制（RR =0.47,95％ CI为0.31 ～0.71,P=0.000 3）及减少肝功能损害（RR =0.63,95％ CI为0.42～ 0.93,P=0.02）.结论 斑蝥酸钠维生素B6注射液辅助治疗中晚期肝癌,不仅可提高患者近期疗效和生活质量,而且还可降低不良反应的发生率,值得推广应用.Objective To evaluate the effectiveness and safety of disodium cantharidinate and vitamin B6 injection in the adjuvant treatment for patients with hepatocellular carcinoma （HCC）.Methods The pertinent literature of adjuvant treatment with disodium cantharidinate and vitamin B6 injection for patients with HCC were searched in Embase,PubMed,Cochrane Library,Chinese Biomedicine Literature Database,VIP Database,China National Knowledge Infrastructure Database （CNKI） and Wanfang Database.Meta analysis was carried out using Review Manager （version5.0） provided by Cochrane Collaboration.Results Four randomized controlled trials totaling 307 patients were included.Results showed that compared to control group,the adjuvant treatment with disodium cantharidinate and vitamin B6 injection significantly enhanced the short-term effect [RR =1.40,95％ CI （1.04,1.89）,P =0.03] and improved the quality of life [RR =1.67,95％ CI （1.28,2.17）,P =0.000 1].Moreover,the combination of disodium cantharidinate and vitamin B6 injection alleviated gastrointestinal reaction [RR =0.62,95％ CI （0.42,0.93）,P =0.02],bone marrow depression [RR =0.47,95 ％ CI （0.31,0.71）,P =0.000 3] and injury of liver function [RR =0.63,95 ％ CI （0.42,0.93）,P =0.02].Conclusion Disodium cantharidinate and vitamin B6 injection can enhance the effectiveness,improve the quality of life and decrease the adverse effect rate in patients with intermediate or advanced HCC,and it is worth popularizing and applying.

关 键 词：肝肿瘤 肿瘤辅助疗法 随机对照试验 META分析 斑蝥酸钠维生素B6注射液 

分 类 号：R735.7[医药卫生—肿瘤]