Ligand Perception,Activation,and Early Signaling of Plant Steroid Receptor Brassinosteroid Insensitive 1  

作　　者：Jianjun JiangWang Chi ZhangWang Xuelu Wang 

机构地区：[1]State Key Laboratory of Genetic Engineering and Institute of Plant Biology,School of Life Sciences,Fudan University

出　　处：《Journal of Integrative Plant Biology》2013年第12期1198-1211,共14页植物学报（英文版）

基　　金：supported by the National Natural Science Foundation of China to X.W.(91117005 and 30925020);National Basic Research Program of China to X.W.(2012CB114300);Key Project of Shanghai Science and Technology Committee to X.W.(10JC1400800);Program of Shanghai Subject Chief Scientist to X.W.(11XD1400700)

摘　　要：Leucine-rich repeat receptor-like kinases （LRR-RLKs） belong to a large group of cell surface proteins involved in many aspects of plant development and environmental responses in both monocots and dicots. Brassinosteroid insensitive 1 （BRI1）, a member of the LRR X subfamily, was first identified through several forward genetic screenings for mutants insensitive to brassinosteroids （BRs）, which are a class of plant-specific steroid hormones. Since its identification, BRI1 and its homologs had been proved as receptors perceiving BRs and initiating BR signaling. The co-receptor BRIl-associated kinase 1 and its homologs, and other BRI1 interacting proteins such as its inhibitor BRI1 kinase inhibitor I （BKI1） were identified by genetic andbiochemical approaches. The detailed mechanisms of BR perception by BRI1 and the activation of BRI1 receptor complex have also been elucidated. Moreover, several mechanisms for termination of the activated BRI1 signaling were also discovered. In this review, we will focus on the recent advances on the mechanism of BRI1 phosphorylation and activation, the regulation of its receptor complex, the structure basis of BRI1 ectodomain and BR recognition, its direct substrates, and the termination of the activated BRI1 receptor complex.Leucine-rich repeat receptor-like kinases （LRR-RLKs） belong to a large group of cell surface proteins involved in many aspects of plant development and environmental responses in both monocots and dicots. Brassinosteroid insensitive 1 （BRI1）, a member of the LRR X subfamily, was first identified through several forward genetic screenings for mutants insensitive to brassinosteroids （BRs）, which are a class of plant-specific steroid hormones. Since its identification, BRI1 and its homologs had been proved as receptors perceiving BRs and initiating BR signaling. The co-receptor BRIl-associated kinase 1 and its homologs, and other BRI1 interacting proteins such as its inhibitor BRI1 kinase inhibitor I （BKI1） were identified by genetic andbiochemical approaches. The detailed mechanisms of BR perception by BRI1 and the activation of BRI1 receptor complex have also been elucidated. Moreover, several mechanisms for termination of the activated BRI1 signaling were also discovered. In this review, we will focus on the recent advances on the mechanism of BRI1 phosphorylation and activation, the regulation of its receptor complex, the structure basis of BRI1 ectodomain and BR recognition, its direct substrates, and the termination of the activated BRI1 receptor complex.

关 键 词：Brassinosteroid insensitive 1-associated kinase 1 brassinosteroid insensitive 1 kinase inhibitor 1 BRASSINOSTEROIDS brassinosteroidinsensitive 1 PHOSPHORYLATION receptor-like kinase recognition signaling. 

分 类 号：Q946[生物学—植物学]