BAK1 Directly Regulates Brassinosteroid Perception and BRI1 Activation  

作　　者：Kai He Shengbao Xu Jia Li 

机构地区：[1]Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations,School of Life Sciences,Lanzhou University

出　　处：《Journal of Integrative Plant Biology》2013年第12期1264-1270,共7页植物学报（英文版）

基　　金：supported by the grants from the National Natural Science Foundation of China to J.L.(91117008 and 90917019);National Basic Research Program of China to J.L.(2011CB915401);Fundamental Research Funds for the Central Universities to S.X.(lzujbky-2009-35)

摘　　要：Plants utilize plasma membrane-localized receptor-like kinases （RLKs） to sense extracellular signals to coordinate growth, development, and innate immune responses. BAK1 regulates multiple signaling pathways acting as a co-receptor of several distinct ligand-binding RLKs. It has been debated whether BAK1 serves as an essential regulatory component or only a signal amplifier without pathway specificity. This issue has been clarified recently. Genetic and structural analyses indicated that BAK1 and its homologs play indispensible roles in mediating brassinosteroid （BR） signaling pathway by directly perceiving the ligand BR and activating the receptor of BR, BRII. The mechanism revealed by these studies now serves as a paradigm for how a pair of RLKs can function together in ligand binding and subsequent initiation of signaling.Plants utilize plasma membrane-localized receptor-like kinases （RLKs） to sense extracellular signals to coordinate growth, development, and innate immune responses. BAK1 regulates multiple signaling pathways acting as a co-receptor of several distinct ligand-binding RLKs. It has been debated whether BAK1 serves as an essential regulatory component or only a signal amplifier without pathway specificity. This issue has been clarified recently. Genetic and structural analyses indicated that BAK1 and its homologs play indispensible roles in mediating brassinosteroid （BR） signaling pathway by directly perceiving the ligand BR and activating the receptor of BR, BRII. The mechanism revealed by these studies now serves as a paradigm for how a pair of RLKs can function together in ligand binding and subsequent initiation of signaling.

关 键 词：ARABIDOPSIS BAK1 BRASSINOSTEROID BRI1 CO-RECEPTOR extracellular domain leucine-rich repeat RECEPTOR receptor-like kinase. 

分 类 号：Q946[生物学—植物学]