一种光纤压力传感器测量食管曲张静脉压力的方法  

A fiber-optic pressure sensor for measuring esophageal variceal pressure

作　　者：余芳芳[1] 王进广[1] 何兵兵 吴艾久 孙斌[1] 庄小金 许建明[1] 孔德润[1] 

机构地区：[1]安徽医科大学第一附属医院消化内科,安徽省合肥市230022 [2]合肥优尔电子科技有限公司,安徽省合肥市230000 [3]江苏常州市久宏医疗器械有限公司,江苏省常州市213162

出　　处：《世界华人消化杂志》2014年第2期221-226,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;Nos.81070337;81271736;安徽省教育厅自然科学重点研究基金资助项目;No.KJ2012Z189;安徽省卫生厅医学科研课题基金资助项目;No.2010B018~~

摘　　要：目的:探讨一种光纤压力传感器测量食道曲张静脉压力的可行性及临床应用价值.方法:采用光纤传感器食道曲张静脉压力检测技术,对体外模拟血管(直径5 mm)进行压力测量(压力范围6-42 cmH2O)测量.测压由两名独立操作者完成,比较测压值与模拟血管内实际压力值.临床试验则利用相同技术对25例门脉高压食道曲张静脉进行压力检测,并与曲张静脉出血风险因素进行相关性分析.结果:体外实验发现,模拟曲张静脉的测压值与实际压力值具有良好相关性(r≥0.99,P<0.01),两名操作者之间测得压力值相关性高(r≥0.99).临床研究25例患者食管曲张静脉压力检测均获得成功,可重复性好,变异系数小(r≥0.99).食管曲张静脉压力与既往出血史、血管直径、红色征、Child-Pugh分级有相关性(t=4.42,P<0.01).结论:初步发现光纤压力传感器体内外验证的可靠性、可行性,值得进一步研究.AIM： To test the feasibility and validity of a fiber-optic pressure sensor for measuring esophageal variceal pressure. METHODS： A fiber-optic pressure sensor was used to measure the pressure of artificial variceal model （5 mm in diameter） with different intraluminal pressures （ranging from 6 to 42 cmH2O）. Pressure measurements were performed by two independent operators, and the results were compared with actual intraluminal pressures. In clinical tests, the technique was used to measure variceal pressure in 25 patients with esophageal varices, and the correlation between variceal pressure and the risk factors for esophageal variceal bleeding was analyzed. RESULTS： In vitro studies demonstrated a good correlation between the pressure measured with the fiber-optic pressure sensor and the actual intravariceal pressure （r ≥ 0.99 P 〈 0.01）, and there were good correlations between the pressures measured by two operators （r ≥ 0.99）. The determination of variceal pressure by this method was technically successful in all 25 patients. The variceal pressure measurements correlated with previous variceal bleeding history, the size of varices, the presence of red colour signs and the Child-Pugh classification （t = 4.42, P 〈 0.01）. CONCLUSION： Our preliminary results indicate that the fiber-optic pressure sensor is feasible and accurate in measurement of esophageal variceal pressure in vivo and in vitro, and warrants further investigation.

关 键 词：食管静脉曲张 压力 光纤压力传感器 

分 类 号：R575.2[医药卫生—消化系统]