前列腺基底细胞癌5例临床病理特征分析并文献复习  

Clinicopathologic characteristics of basal cell carcinoma of the prostate: Analysis of 5 cases and review of the literature

作　　者：王瑜[1] 郭鹏[1] 刘清松[1] 谢孝川 谷从阳 敬敏[1] 刘贵平[1] 

机构地区：[1]内江市第一人民医院病理科,四川内江641000

出　　处：《中华男科学杂志》2014年第2期160-164,共5页National Journal of Andrology

摘　　要：目的:探讨前列腺基底细胞癌(basal cell carcinoma of prostate)的发生、临床病理特点、病理诊断、鉴别诊断以及治疗和预后。方法:运用HE染色及免疫组化染色对5例前列腺基底细胞癌进行临床病理学分析,并结合相关文献进行分析。结果:前列腺基底细胞癌癌细胞排列成筛孔状或实性巢状,细胞体积较小,细胞核大并呈卵圆形,大小一致,胞质少,可见核分裂像。肿瘤呈浸润性生长,肿瘤组织中34βE12、P63、CK14呈阳性表达,PSA、P504S蛋白常呈阴性表达。术后随访至少12个月以上,均未见肿瘤复发及转移。结论:前列腺基底细胞癌为一种不同于前列腺腺癌的罕见肿瘤,免疫组化对于鉴别前列腺基底细胞癌和其他肿瘤有重要的作用,其生物学行为尚有争议,目前多数学者主张通过完整切除并联合放化疗的方式来治疗。Objective： To investigate the histogenesis, clinicopathologic characteristics, pathologic diagnosis, differential diag- nosis, treatment and prognosis of basal cell carcinoma of the prostrate （BCCP）. Methods ： We conducted clinicopathologic analysis on the manifestations of 5 cases of BCCP by HE staining and immunohistochemistry and reviewed relevant literature. Results ： Micro- scopically, the tumor cells were small in volume with ovoid karyomegaly and mitosis, some arranged like a solid nest or with a cribri- form appearance. The tumors displayed an invasive growth, with positive expressions of 3413E12, P63 and Cytokeratin 14, and negative expressions of PSA and PS04s. No recurrence and metastasis were found in these patients during over 12 months of follow-up after sur- gery. Conclusion ： BCCP is a rare neoplasm different from prostate adenocarcinoma. Immunohistochemistry is indispensable in distin- guishing this tumor from other types of prostatic carcinoma. Its biological behavior remains to be further studied. The best treatment op- tion may be radical surgery combined with chemo-radiotherapy at the present time.

关 键 词：前列腺 肿瘤 基底细胞癌 

分 类 号：R737.25[医药卫生—肿瘤]