性别与症状性颅内动脉粥样硬化性狭窄关系的研究  

Relationship between sex and symptomatic intracranial atherosclerotic stenosis

作　　者：曹裕民[1,2] 张雄[1] 万鑫[1] 王硕[1] 代成波[1] 马桂贤[1] 张玉虎[1] 王丽娟[1] 

机构地区：[1]广东省人民医院(广东省医学科学院)神经内科广东省神经科学研究所,广州510080 [2]汕头大学医学院医学院

出　　处：《中华老年心脑血管病杂志》2014年第1期62-65,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：广东省科技计划项目(2012B031800410)

摘　　要：目的 探讨性别与症状性颅内动脉粥样硬化性狭窄的关系,为颅内动脉粥样硬化性狭窄危险因素的研究及缺血性脑血管病的防治提供理论依据.方法 回顾性分析行数字减影血管造影术检查的缺血性脑血管病患者3708例,未见明显颅内外动脉狭窄1476例,症状性颅内外动脉狭窄2232例,分析症状性颅内外动脉狭窄与性别及年龄的关系.结果 症状性颅内外动脉狭窄患者中,单纯颅内动脉狭窄发生率明显高于单纯颅外动脉狭窄和颅内外动脉联合狭窄（48.3% vs 25.2% vs 26.5%）,且男性比例明显大于女性（68.8% vs 31.2%,P〈0.01）.与≤40岁比较,41~64岁、65~79岁、≥80岁单纯颅内动脉狭窄比例明显降低,单纯颅外动脉狭窄、颅内外动脉联合狭窄比例明显升高（P〈0.01）;与41~64岁比较,65~79岁、≥80岁单纯颅内动脉狭窄比例明显降低,单纯颅外动脉狭窄、颅内外动脉联合狭窄比例明显升高（P〈0.01）.结论 中国人性别差异与症状性颅内动脉粥样硬化性狭窄的发生有关,男性发生率可能高于女性.症状性颅内动脉粥样硬化性狭窄的分布具有年龄特征性.Objective To provide the evidence for the risk factors of symptomatic intraeranial artery stenosis, and the prevention and control of ischemic eerebrovascular diseases by studying the rela- tionship between sex and symptomatic intracranial atherosclerotic stenosis. Methods Relation- ship of symptomatic intracranial atherosclerotic stenosis with sex and age was retrospectively ana- lyzed in 3708 patients with DSA-confirmed isehemic eerebrovaseular diseases（1476 without signif leant intracranial and extraxranial artery stenosis and 2232 with symptomatic intracranial and ex- traxranial artery stenosis）. Results The incidence of simple intracranial artery stenosis was sig- nificantly higher than that of simple extracranial artery stenosis and combined intracranial and ex- traeranial artery stenosis in patients with symptomatic intraeranial and extracranial artery stenosis （48.3% vs 25.2% vs 26.5%,P〈0.01） and in males than in females （68.8%vs 31.2%,P〈 0.01）. The incidence of simple intracranial artery stenosis was significantly lower whereas that of simple extracranial artery stenosis and combined intracranial and extracranial artery stenosis was significantly higher in 41 64,65 79 and ≥80 years old patients than in 440 years old patients and in 65-79 and ≥80 years old patients than in 41-64 years old patients （P〈0.01）. Conclusion Sex is related with symptomatic intracranial atheroselerotic stenosis in Chinese populations. Its in cidence is higher in males than in females and its distribution is characterized by age.

关 键 词：颅内动脉硬化 血管造影术 数字减影 脑梗死 脑缺血发作 短暂性 体征和症状 性别因素 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]