肝脏细胞在生物活性物质代谢调控中的协作作用  

Cooperation of Liver Cells in the Metabolism Regulation of Bioactive Substances

作　　者：李严严[1,2] 郝运伟[1] 姜颖[1] 贺福初[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京蛋白质组研究中心,蛋白质组学国家重点实验室,北京102206 [2]清华大学生命科学学院,北京100086

出　　处：《中国科学：生命科学》2014年第2期175-184,共10页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:81123001)资助项目

摘　　要：肝实质细胞和非实质细胞是肝脏功能的物质和结构基础.肝实质细胞是肝脏的主要细胞类型之一,承担和执行肝脏代谢、信号转导、解毒和稳态调节等多种功能.而非实质细胞也必不可少,主要包括星型细胞、肝窦内皮细胞、枯否细胞、自然杀伤细胞和隐窝细胞等,具有物质和信号转运、吞噬、抗原提呈、免疫耐受等功能.目前,有关肝脏生理功能和病理机制的研究主要集中在组织、细胞和差异分子的水平,单细胞的生理和病理功能研究也越来越深入,而肝脏细胞协作的研究比较少,系统性总结也鲜有报道.本文从肝脏细胞相互协作的角度,对肝脏的生理功能及病理机制进行探讨,为全面了解肝细胞生理功能及肝脏疾病的致病机理提供参考.Hepatocyte and nonparenchymal cells are the key foundation of liver structure and function. Hepatocyte is one of the main liver cell types, involved in large physiological processes, such as material metabolism, detoxication, and homeostasis. On the other hand, the nonparenchymal cells, including hepatic stellate cell, liver sinusoidal endothelial cell, kupffer cell, natural killer cell and pit cell, perform the material transportation, phagocytose, antigen presentation and immune tolerance. However, at present there is few research on cell cooperation between hepatocyte and the nonparenchymal cells in liver physiological and pathological process. This paper aims to comprehensively summarize the interaction between different kinds of liver cells both in health and disease conditions to provide references for further studies of the specific molecular mechanism of liver diseases.

关 键 词：肝实质细胞 非实质细胞 肝细胞协作 代谢调控 

分 类 号：R575[医药卫生—消化系统]