利动治疗肝硬化并发C型肝性脑病的临床观察  

Clinical observation on lactulose oral solution in the treatment of hepatocirrhosis complicated with type C hepatic encephalopathy

作　　者：刘晓丽[1] 周纯智 

机构地区：[1]辽宁省铁岭市中心医院感染内科,辽宁铁岭112000 [2]辽宁省铁岭市卫生职业学院临床教研室,辽宁铁岭112000

出　　处：《中国医药科学》2014年第1期103-105,共3页China Medicine And Pharmacy

摘　　要：目的观察利动(66.7%乳果糖)口服溶液治疗肝硬化并发C型肝性脑病的疗效及安全性。方法根据患者的不同的经济状况及自身意愿,将肝硬化并发C型肝性脑病的住院患者78例分为治疗组(n=39)和对照组(n=39),治疗组给予利动及常规治疗,对照组予利福昔明加常规治疗。于治疗前及治疗后24h、14d按照国外广泛使用的简易肝性脑病严重程度评分表(CHESS)进行程度评定并记录不良反应。结果与治疗前相比,治疗后24h、14d两组CHESS评分均下降[治疗组:(5.8±3.1)VS(2.1±2.0),P<0.05;对照组:(5.9±3.0)VS(3.6±2.5),P<0.05)],治疗组优于对照组(P<0.05)。结论利动可明显改善肝性脑病所致的神经精神障碍,疗效优于利福昔明加常规治疗,并可改善远期预后,安全性良好。Objective To observe the efficacy and safety of lactulose oral solution（66.7% lactulose） in the treatment of hepatocirrhosis complicated with type C hepatic encephalopathy. Methods Seventy-eight inPatients with hepatoeirrhosis complicated with type C hepatic encephalopathy were divided into the treatment group（n=39） and the control group（n=39） according to the different economic status of patients and their wishes. The patients in the treatment group were given lactulose oral solution and routine treatment, while the patients in the control group were given rifaximin and routine treatment. The degree of hepatic encephalopathy of patients were evaluated by foreign extensive use of clinical hepatic encephalopathy staging scale（CHESS） before the treatment and at 24h and＇ 14d after the treatment, and the adverse reactions of patients were recorded. Results Compared with before the treatment, the CHESS score of two groups decreased at 24h and 14d after the treatment（the treatment group： （5.8 ±3.1） VS （2.1 ± 2.0）, P 〈 0.05; the control group： （5.9 ± 3.0） VS （3.6 ± 2.5）, P 〈 0.05, the curative effect of the treatment group was better than that of the control group（P 〈 0.05）. Conclusion Lactulose oral solution can obviously improve the neuropsychiatric disorders caused by hepatic encephalopathy, and the curative effect of lactulose oral solution is better than that of rifaximin and routine treatment, and can improve the long-term prognosis, has a good safety.

关 键 词：肝性脑病 肝硬化 乳果糖 利福昔明 

分 类 号：R575.2[医药卫生—消化系统] R747.9[医药卫生—内科学]