胶质瘤患者术后注意功能损伤的临床研究  

Attention dysfunction of postoperative glioma patients

作　　者：方大钊[1] 孙晓阳[1] 王伟杰[1] 董楠[1] 付宪华[1] 丁涟沭[1] 

机构地区：[1]南京医科大学附属淮安第一医院神经外科,淮安223300

出　　处：《中华神经医学杂志》2014年第2期165-168,共4页Chinese Journal of Neuromedicine

基　　金：江苏省医学重点人才基金（RC2007029）;江苏省社会发展项目（BS2007037）

摘　　要：目的研究胶质瘤患者术后注意功能损伤情况，探讨肿瘤部位、病理分级及术后恢复时间与注意功能损伤的关系。方法应用注意网络功能测验（ANT）、注意广度测验（DSl、数字颜色连线测验Ⅱ（CTTⅡ）、Stroop词色干扰测验（ST）检测南京医科大学附属淮安第一医院神经外科自2010年1月至2012年1月收治的45例胶质瘤患者和18例健康对照者的注意功能特点，分析肿瘤部位、病理分级和术后恢复时间与注意功能损伤的关系。结果与对照组相比，额叶肿瘤组执行网络功能下降，顶叶肿瘤组定向和执行网络功能均下降，差异有统计学意义（P〈0．05）。与低级别组（Ⅰ一Ⅱ级）比较，高级别组（Ⅲ-Ⅳ级）患者DS测试中倒背评分较低、数字颜色连线时间较长，词色命名干扰值较高，差异有统计学意义（P〈0．05）。而术后恢复时间不同患者DS、CTTⅡ和ST结果比较差异无统计学意义俨〉0．05）。结论额叶和顶叶胶质瘤患者术后注意功能下降，且高级别肿瘤患者集中注意力、注意转换效应及选择性注意能力较低级别患者下降。Objective To study the attention dysfimction of postoperative glioma patients. Methods Attention network test （ANT）, digital span （DS）, color trail test II （CTT II） and stroop test （ST） were used to detect the characteristics of attention function of 45 postoperative glioma patients, admitted to our hospital from January 2010 to January 2012 and 18 healthy controls. The relations of attention dysfunction with rumor localization, malignancy and postoperative recovery time were analyzed. Results As compared with that in the control group, orientation network dysfunction was detected in parietal lobe tumor group, with significant difference （P〈0.05）; as compared with patients with low grade tumors （grade MI）, the patients with high grade tumors （grade IIMV） had significantly lower scores in backward recite test, longer time in digital color connection test and higher word color naming interference value, enjoying significant differences （P〈0.05）. No significant relation was observed between postoperative recovery time and attention impairment （P〉0.05）; Conclusion The frontal and parietal lobe glioma patients suffer attention dysfunction and the high-grade glioma patients have more seriously impairment in attention, attention switching effect and selective attention ability than the low-grade ones.

关 键 词：神经胶质瘤 注意网络 注意广度 数字颜色连线测验 词色干扰测验 

分 类 号：R739.4[医药卫生—肿瘤]