缺血性脑血管病患者脑白质病变危险因素的研究  

Risk factors of white matter lesion in patients with ischemic cerebrovascular disease

作　　者：范常锋[1] 

机构地区：[1]北京大学首钢医院,北京100041

出　　处：《现代中西医结合杂志》2014年第7期707-709,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨缺血性脑血管病患者脑白质病变(WML)的相关危险因素。方法选取缺血性脑血管病患者132例。对所有患者行头部MRI(包括FLAIR及DWI序列)检查。脑白质病变采用ARWMC评分方法。采用多因素Logistic回归分析的方法分析脑白质病变的危险因素。结果①脑白质病变与年龄、高血压病、高同型半胱氨酸血症、血红蛋白水平有显著相关性(P均<0.05)。②年龄、高同型半胱氨酸血症是WML的独立危险因素。低血红蛋白水平为偏危险因素。结论年龄、高同型半胱氨酸血症是WML的独立危险因素。Objective It is to investigate the correlated risk factors of white matter lesion（WML） in the patients with ische- mic eerebrovascular disease. Methods 132 patients with ischemic cerebrovascular disease were selected and given head MRI examination （including FLAIR and DWI sequence）. WML was evaluated with ARWMC score. Multivariate logistic regression method was used to analyze the independent risk factors for severe WML. Results Multivariate analysis indicated that age,inci- dence of hypertension, high plasma Hey level and HB level were significantly related with WMI（ P 〈 0.05 ）. Age, high plasma Hcy level were shown to be independent risk factors for severe WML in stroke patients by multivariate logistic regression analy- sis. Conclusion Age,hyperhomoeysteinemia are independent risk factors for severe WML in stroke patients.

关 键 词：脑白质病变 危险因素 高同型半胱氨酸 低血红蛋白水平 

分 类 号：R743[医药卫生—神经病学与精神病学]