多发性骨髓瘤患者骨髓中 Treg 细胞与预后相关性研究  

Analysis of Treg in bone marrow of patients with multiple myeloma and its correlation with clinical prog-nostic factors

作　　者：郭秀臣[1] 全丽娜[1] 李红[1] 李莲乔[1] 郭微媛[2] 贾垂明[1] 

机构地区：[1] 哈尔滨医科大学附属肿瘤医院, 哈尔滨 150081 [2] 哈尔滨医科大学附属第二医院检验科

出　　处：《实用肿瘤学杂志》2014年第1期54-58,共5页Practical Oncology Journal

摘　　要：目的：检测多发性骨髓瘤（Multiple myeloma，MM）患者及正常人外周血和骨髓Treg细胞水平，评价MM患者骨髓微环境的免疫状态，以及免疫状态与疾病水平的相关性。方法采用流式细胞术检测45例MM患者外周血以及骨髓中Treg细胞水平，15例正常人外周血及骨髓中Treg细胞水平。以CD4^＋CD25high^＋细胞占CD4＋细胞的百分比代表Treg细胞水平。结果 MM患者外周血Treg细胞高于正常人外周血，MM患者骨髓中Treg细胞低于正常人骨髓，MM患者骨髓微环境中Treg细胞降低水平与浆细胞比例无关，而与疾病的预后相关，与β2-MG水平及ISS相关。结论 MM骨髓微环境中肿瘤诱导的免疫系统的改变是MM发病的原因之一，MM患者骨髓中Treg细胞降低比例与预后相关，而与肿瘤负担无关。Objective To evaluate immune function of patients with multiple myeloma （ MM） by detect the changes of the Treg cells in bone marrow of patients with MM .Methods Treg cells in peripheral blood and bone marrow of 45 patients with MM and 15 healthy controls were measured by flow cytometry .Results The per-centage of Treg cells in peripheral blood of MM was higher than that in healthy person ;The percentage of Treg cells in MM bone marrow was lower than that in healthy person ,and the extent was positively correlated with the level of β2-MG and ISS（P〈0.05）.Conclusion MM Patients display an abnormal level of CD4^＋CD25^＋Treg cells,which may be an important mechanism of MM immune deficiency .

关 键 词：多发性骨髓瘤 骨髓微环境 TREG细胞 

分 类 号：R730.4[医药卫生—肿瘤]