中性粒细胞—淋巴细胞比率与肺癌临床病理特征的关系  

Association between NLR and clinicopathologic features of patients with lung cancer

作　　者：帅欣艳[1] 韩觉明[1] 徐晓娅[1] 姜曼[1] 毕玉莉[1] 韩明勇[1] 

机构地区：[1]山东大学附属省立医院,济南250021

出　　处：《山东医药》2014年第6期1-3,共3页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(81272351);山东省自然科学基金资助项目(2R2012HM020);山东省科技发展计划资助项目(2012G0021826)

摘　　要：目的探讨中性粒细胞—淋巴细胞比率(NLR)与肺癌临床病理特征的关系。方法收集行手术治疗的234例肺癌患者的一般信息、术前中性粒细胞计数、淋巴细胞计数、手术方式及术后病理等临床病理特征资料,分析NLR(血常规中性粒细胞计数/淋巴细胞计数)与肺癌临床病理特征的关系。结果男性、有吸烟史、病理分期晚、分化程度低的患者NLR较高;高NLR者中男性患者、吸烟患者比例更高,肿瘤最大径较大,肿瘤分期晚。结论 NLR与肺癌患者性别、吸烟史、分期及分化程度相关,NLR增高提示肿瘤分期偏晚、肿瘤较大。NLR可作为肺癌患者的常规检查项目,可为判断患者预后提供依据。Objective To explore the relationship between neutrophil-to-lymphocyte ratio （NLR） and the clinicopathologic features of patients with lung cancer.Methods A total of 234 patients who underwent complete resection for lung cancer were included.The NLR was calculated from the differential count by dividing the absolute neutrophil count by the absolute lymphocyte count.And then the association between NLR and clinicopathologic features of lung cancer was analyzed.Results Male patients,patients with a smoking history or patients with advanced lung cancer had a high NLR.In the high-NLR group,the proportion of male patients and patients with a smoking history was higher,and the tumor size was larger than that of patients in the low-NLR group.The tumor stage of patients in the high-NLR group was more advanced than that of patients in the]ow-NLR group.Conclusions NLR is associated with gender,smoking history,tumor stage and differentiation in patients with lung cancer.The elevated NLR shows that tumor stage is late,and tumor is large.NLR can be used as a routine examination of patients with lung cancer,which can provide the basis for judging the prognosis of the patients.

关 键 词：中性粒细胞—淋巴细胞比率 肺癌 预后 

分 类 号：R734.2[医药卫生—肿瘤]