c-M yc和 COX-2在宫颈鳞癌组织中的表达及临床意义  

Expression of c-Myc and COX-2 in Cervical Squamous Carcinoma and Its Significance

作　　者：刘平[1] 王雅楠[2] 孔卫平[2] 

机构地区：[1] 河北省邯郸市中心医院,河北 邯郸056001 [2] 河北省邯郸市妇幼保健院,河北 邯郸056002

出　　处：《医学临床研究》2014年第1期107-109,共3页Journal of Clinical Research

摘　　要：[目的]探讨原癌基因（c-Myc）和环氧合酶-2（COX-2）在年轻宫颈鳞癌（SCC）中的表达、微血管密度（MVD）及临床意义。[方法]选择年轻女性SCC组织标本40份、宫颈上皮内瘤变（CIN）标本31份，正常宫颈组织（NCE）10份，采用免疫组化SP法检测各组c-Myc、COX-2的表达水平和MVD ，分析其表达与肿瘤分期、病理分型、淋巴结转移等相关性。[结果]SCC中c-M yc 、COX-2的阳性表达率分别为62．5％（25/40）、67．5％（27/40），均显著高于 CIN 组和 NCE组（ P ＜0．01）；c-Myc表达与分化及淋巴结转移有关（ P ＜0．01），与分期无关；COX-2的表达与SCC的分期及淋巴结转移有相关性（ P ＜0．01）；NCE、CIN、SCC组中M VD呈逐渐升高趋势，在SCC组中c-M yc 、COX-2阳性表达和阴性表达的M VD值具有明显相关性（ P ＜0．01）；SCC组织中c-Myc 、COX-2表达呈正相关。[结论]c-Myc和COX-2在SCC发生、发展中起重要作用，两者在宫颈癌血管生成中有协调作用。[Objective] To explore the expression of proto-oncogen gene c-Myc and cyclooxygenase-2 （COX-2） in young patients with squamous carcinoma of the cervix （SCC） ,microvessel density （MVD） and their significance .[Methods] The samples of 40 SCC tissues ,31 cervical intraepithelial neoplasia（CIN） and 10 normal cervical tissues （NCE） were collected .Immunohistochemical SP method was used to detect the expres-sions of COX-2 ,c-Myc and microvessel density （MVD） .The correlation of the expression with tumor stage , pathological type and lymph node metastasis was analyzed .[Results] The positive expression rates of c-Myc and COX-2 in SCC were 62 .5% （25/40） and 67 .5% （27/40） respectively ,which were significantly higher than those in CIN group and NCE group（ P〈0 .01） .The expression of c-Myc was related to the differentiation and lymph node metastasis（ P 〈0 .01） ,but not related to the staging .The expression of COX-2 had the correla-tion with the staging and lymph node metastasis of SCC （ P 〈 0 .01） .MVD in NCE ,CIN and SCC groups showed a trend of rising .The positive and negative expression of c-Myc and COX-2 in SCC group had obvious correlation with MVD（ P〈0 .01） .The expression of c-Myc in SCC group was positively related to the expres-sion of COX-2 .[Conclusion]COX-2 and c-Myc play an important role in the occurrence and development of SCC .Both of them have synergistic effect in the angiogenesis of cervical cancer .

关 键 词：宫颈肿瘤 病理学 癌 鳞状细胞 基因 MYC 

分 类 号：R737.33[医药卫生—肿瘤]