多胺代谢与肿瘤细胞信号转导  

Polyamine Metabolism and Signaling Transduction in Tumor Cells

作　　者：王清[1] 王艳林[1] 曹春雨[1] 

机构地区：[1]三峡大学医学院分子生物学研究所,宜昌443002

出　　处：《生物技术通报》2014年第1期58-62,共5页Biotechnology Bulletin

基　　金：国家自然科学基金资助项目(30772590);三峡大学培优基金资助项目(2013PY052)

摘　　要：肿瘤细胞的快速增殖依赖于细胞内的多胺水平,耗竭细胞内多胺可抑制肿瘤细胞增殖并诱导其凋亡。与此同时,细胞内多胺含量的改变可以影响肿瘤细胞内多种信号通路的活性,依据受影响信号分子功能的差异,这些信号通路活性的改变具有增强或抑制耗竭多胺产生的抗肿瘤效应的功能,从而对肿瘤细胞的生长、分化、迁移和侵袭产生不同的影响。综述多胺对肿瘤相关信号通路的影响及其分子机制。The rapid growth of tumor cells depends on their higher intracellular polyamine levels compared to normal cells. Depletion of intracellular polyamine could inhibit tumor cells＇ proliferation and induce tumor cells apoptosis. It is worth noting that, the alteration of the intraccllular polyamine concentration have an obvious effect on multiple cell signal transduct in tumor cells. Because of the functional diversity and complexity of cell signalling molecules, the regulation of these signaling pathways activity result in both activated or suppressive effect on tnmor cell survival, differentiation, migration and invasion. This article summarized the effects of polyamines metabolism on tumor-associated and the undcrlvin molecular mechanism.

关 键 词：多胺 多胺代谢 肿瘤 信号转导 

分 类 号：R730.2[医药卫生—肿瘤]