复方长循环肿瘤靶向制剂的研究进展  

Advance in studies on long-circulating tumor targeted compound preparations

作　　者：李秋萍[1] 刘小蔓[1] 戴俊东[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中国中药杂志》2014年第3期402-406,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30801549);北京中医药大学复方中药制剂研究创新团队发展计划项目(2011-CXTD-13)

摘　　要：肿瘤一直是世界医疗界难以攻克的难题,其发生发展过程中微环境多种因素的干预,使常规药物的效果有限。复方长循环靶向制剂以其高效、低毒、多靶点协同作用的特点,在改善肿瘤微环境,提高肿瘤治疗效果方面表现出特有的优势,现已逐渐成为国内外研究的热点。该文通过查阅近年来国内外专业文献,对不同载体复方长循环肿瘤靶向制剂的体内外研究现状进行综述,以期为复方长循环肿瘤靶向制剂的发展提供新的思路和方法。Tumor has long been a hard-nut problem in the world medical field. The effect of the conventional drugs is very limited because of the intervention of multiple micro-environmental factors during the occurrence and progression of tumors. With the characteristics of high efficiency, low toxicity and multi-targets synergistic effect, the long-circulating tumor targeted compound preparations show its unique advantages in improving tumor microenvironment and enhancing the therapeutic effect of treatment, thus it has gradually become a hotspot of studies both at home and abroad. Through consulting a great number of professional literatures at home and abroad in recent years, the authors summarized the current studies in vitro and in vivo on long-circulating tumor targeted compound preparations in different carriers, in the expectation of providing new ideas and methods for the development of long-circulating tumor targeted compound preparations.

关 键 词：复方 长循环肿瘤靶向制剂 脂质体 纳米粒 静脉乳剂 

分 类 号：R730.5[医药卫生—肿瘤]