独蒜兰的化学成分研究  

Chemical constituents from Pleione bulbocodioides

作　　者：王超 韩少伟[1] 崔保松[1] 王晓娟[1] 李帅[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京100050

出　　处：《中国中药杂志》2014年第3期442-447,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(811733529)

摘　　要：应用硅胶、ODS、大孔树脂、葡聚糖凝胶Sephadex LH-20和HPLC等多种色谱分离方法相结合,从中药山慈菇来源之一——独蒜兰干燥假鳞茎的95%乙醇提取物的醋酸乙酯萃取部位中分离得到14个化合物,其中菲及二氢菲类10个,联苄类2个,木脂素1个,甾醇1个;根据化合物的波谱数据鉴定化合物的结构为monbarbatain A(1),2,7,2'-三羟基-4,4',7'-三甲氧基-1,1'-二聚菲(2),白芨烯A(3),pleionesin B(4),shanciol H(5),{7-hydroxy-7'-(4'-hydroxy-3'-methoxyphenyl)-4-methoxy-9,10,7',8'-tetrahydrophenanthro[2,3-b]furan-8'-yl}methyl acetate(6),2,7-二羟基-1-(对羟基苄基)-4-甲氧基菲(7),2,7-二羟基-1-(对-羟基苄基)-4-甲氧基-9,10-二氢菲(8),赫尔西酚(9),贝母兰宁(10),石斛酚(11),山药素Ⅲ(12),丁香脂素(13),麦角甾-4,6,8(14),22-四烯-3-酮(14)。其中化合物1-3,9,13,14为首次从该属植物中分离得到。Fourteen compoumds were isolated from the ethyl acetate portion of the 95% ethanolic extract of Pleione bulbocodioides by a combination of various chromatographic techniques including silica gel, ODS, macroporous adsorbent resin, Sephadex LH- 20, and preparative HPLC, of which ten compoumds were phenanthrenes and dihydrophenanthrenes, two compoumds were bibenzyls, one was lignan and a sterol. Their structures were identified on the basis of spectroscopic data as monbarbatain A（1）, 2, 7, 2＇-trihy- droxy-4, 4＇, 7＇-trimethoxy-1, 1＇- biphenanthrene（2）, blestriarene A（3）, pleionesin B（4）, shaneiol H（$）, /7-hydroxy-7＇-（4＇-hy- droxy-3＇-methoxyphenyl） - 4 -methoxy-9, 10, 7＇, 8 ＇-tetrahydrophenanthro [ 2, 3-b ] furan-8＇-yl } methyl acetate （ 6 ）, 1 -p -hydroxybenzyl - 4-methoxy phenanthrene-2, 7-diol （7）, 1-p-hydroxybenzyl-4-met-hoxy-9, 10-dihydrophenanthrene-2, 7-diol （ 8 ）, hircinol （ 9 ）, coelonin（10）, gigantol（ll）, batatasin 11I（12）, syringaresinol（13） and ergosta-4, 6, 8（14）, 22-tetraen-3-one（14）. Compounds 1-3, 9, 13 and 14 were isolated from this genus for the first time.

关 键 词：山慈菇 独蒜兰 菲及二氢菲类 联苄类 

分 类 号：R282[医药卫生—中药学]