量子点对雌性鼠类生殖系统及胚胎发育毒性的研究进展  

Research Progress of Toxic Effects of Quantum Dots on Female Mouse Reproductive System and Embryo Development

作　　者：范丽娟[1,2] 许恒毅[2] 傅芬[1] 杨林[2] 刘文婷[1,2] 

机构地区：[1]南昌大学第二附属医院妇产科,南昌330006 [2]南昌大学食品科学与技术国家重点实验室,南昌330047

出　　处：《生殖与避孕》2014年第2期136-142,共7页Reproduction and Contraception

摘　　要：量子点新型半导体纳米微晶因其具有良好的光学特性,在妇科肿瘤诊断及治疗有良好应用前景。目前,量子点的细胞毒性和机体毒性的研究已成为国内外研究热点,但其对雌性生殖系统和胚胎发育的毒性尚未完全阐明。已有对雌性鼠类生殖系统及胚胎发育毒性的最新研究表明量子点对子宫以及乳腺的影响主要是由于其具有很强的雌激素样作用,而其对卵巢的主要作用是抑制卵母细胞的发育及卵巢的内分泌功能;对胚胎及胎盘也有负性作用;同时抑制精卵受精和输卵管伞的拾卵功能。Quantum dots have a bright prospect in the application of diagnosis and treatment of gynecologic oncology for their excellent optical properties. Research on cell toxicity and physical toxicity of quantum dots becomes a hot spot, however, the detailed mechanism their toxicity on female reproductive system and embryonic development remains unknown. Recent researches suggest that quantum dots have an influence on uterus and breast through their strong estrogen-like effects, inhibit oocyte development and ovarian endocrine function, have an negative effect on embryo and placenta, and meanwhile can suppress fertilazation and the picking function of oviduct umbrella egg.

关 键 词：量子点 生殖毒性 胚胎发育 

分 类 号：R737.3[医药卫生—肿瘤]