Borrmann Ⅳ型胃癌的临床病理特点及预后分析  

Clinicopathological features and prognosis of patients with Borrmann type Ⅳ gastric cancer

作　　者：崔景利 邓靖宇[1] 刘宏根[1] 焦旭光[1] 梁月祥[1] 蒋楠[1] 梁寒[1] 

机构地区：[1]天津医科大学肿瘤医院胃部肿瘤科国家肿瘤临床医学研究中心天津市“肿瘤防治”重点实验室,300060

出　　处：《中华普通外科杂志》2014年第2期89-92,共4页Chinese Journal of General Surgery

基　　金：国家重点研究发展计划973计划资助项目（2010CB529301）;天津市科技计划资助项目（12ZCDZSY16400）

摘　　要：目的 比较BorrmannⅣ型胃癌与其他Borrmann型胃癌的临床病理特点,探讨影响BorrmannⅣ型胃癌患者预后的因素.方法 回顾性分析671例进展期胃癌手术患者,比较64例BorrmannⅣ型（9.5％）和607例其他Borrmann分型（90.5％）胃癌患者的临床病理特点及其预后.结果 BorrmannⅣ型胃癌患者在年龄、性别、肿瘤大小、肿瘤部位、组织类型、N分期、远处转移、TNM分期、手术方式与其他Borrmann分型相比差异均有统计学意义（均P＜0.05）.BorrmannⅣ型胃癌患者的5年生存率为20.1％,而其他Borrmann分型胃癌患者为40.3％,差异有统计学意义（P＜0.05）.TNM分期为Ⅰ、Ⅱ、Ⅲ、Ⅳ期时,BorrmannⅣ胃癌患者5年总体生存率分别为50.0％、30.0％、18.0％、16.4％,而其他Borrmann分型的胃癌患者分别为72.0％、57.9％、28.4％、20.0％,差异均有统计学意义（均P＜0.05）.多因素分析显示年龄、分化类型、Borrmann分型和TNM分期是独立的预后因素.结论 Borrmann分型是胃癌一个重要的独立预后因素.BorrmannⅣ型胃癌具有独特的临床病理特征且预后较差.Objective To compare the clinicopathological features of Borrmann type Ⅳ gastric cancer with other gastric cancer and explore prognostic factors of the patients with Borrmann type Ⅳ cancer.Methods We retrospectively reviewed the clinical data of 671 advanced gastric cancer patients.They were divided into 2 groups：Borrmann type Ⅳ （64 cases） and other macroscopic Borrmann types of cancer （607 cases）.Their clinicopathologic characteristics and overall survival data were analyzed.Results Age,sex,tumor size,tumor location,lymph node metastasis,distant metastasis,TNM classification were discrepant between Borrmann type Ⅳ and other macroscopic Borrmann types of cancer.The 5-year survival rate of Borrmann type Ⅳ cancer patients was 20.1%,while it was 40.3% for other types of cancer （P 〈 0.05）.The 5-year survival rate for Borrmann type Ⅳ gastric cancer and the other type gastric cancer was 50.0% and 72.0% at stage Ⅰ,30.0% and 57.9% at stage Ⅱ,18.0% and 28.4% at stage Ⅲ,and 16.4% and 20.0% at stage Ⅳ （all P 〈 0.05）,respectively.Multivariate analyses revealed age,histology differentiation type,tumor size,the Borrmann type carcinoma and tumor stage to be independent prognostic factors for survival.Conclusions Borrmann type carcinoma has unique clinicopathological features compared with other types of gastric carcinoma and is an important independent prognostic factor.

关 键 词：胃肿瘤 病理学 临床 预后 

分 类 号：R735.2[医药卫生—肿瘤]