锌指蛋白A20对炎症反应和细胞凋亡的调控作用及其在炎症性肠病中的影响  

Regulatory effect of zinc finger protein A20 on inflammation and apoptosis: Implications for inflammatory bowel disease

作　　者：季蓉[1] 吴焕淦[2] 施茵[2] 

机构地区：[1]上海中医药大学岳阳临床医学院,上海市200437 [2]上海市针灸经络研究所,上海市200030

出　　处：《世界华人消化杂志》2014年第4期508-514,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81273844;国家重点基础研究发展计划(973计划)基金资助项目;No.2009CB522900~~

摘　　要：锌指蛋白A20,又称肿瘤坏死因子α诱导蛋白3(tumor necrosis factor alpha-induced protein 3,TNFAIP3),是一种具有泛素化和去泛素化双重酶活性蛋白,能负调控多种信号转导途径介导的炎症反应和细胞凋亡,在炎症性疾病[尤其是炎症性肠病(inflammatory bowel disease,I B D)]的发生、发展以及转归中发挥着重要作用.近年来,有关A20蛋白在炎症反应和细胞凋亡中的影响作用已日益受到关注.本文旨从A20的生物学效应以及对肿瘤坏死因子α(tumour necrosis factorα,TNF-α)/肿瘤坏死因子受体-1(tumour necrosis factor receptor 1,TNFR1)、核转录因子-κB(nuclear factorκB,NF-κB)、脂多糖(lipopolysaccharide,LPS)/LPS-NF-κB、氧化低密度脂蛋白(oxidized low density lipoprotein,OxLDL)等途径介导的炎症反应和细胞凋亡及其对IBD的肠道炎症和肠上皮细胞凋亡的负调控作用等方面作一简要概述.Zinc finger protein A20, also known as tumor necrosis factor alpha-induced protein 3 （TN- FAIP3）, is a protein with dual enzyme activi- ties： ubiquitination and deubiquitination. It can negatively regulate inflammation and apoptosis mediated by a variety of signal transduction pathway, playing an important role in the oc- currence, development and prognosis of inflam- matory diseases, especially inflammatory bowel diseases. In recent years, the role of zinc finger protein A20 in inflammation and apoptosis has gained growing concern. This paper gives a brief overview of the biological effects of zinc finger protein A20 on inflammation and apoptosismediated by tumor necrosis factor alpha/tumor necrosis factor receptor 1, nuclear factor kappa B, lipopolysaccharide/lipopolysaccharide - nuclear factor kappa B, oxidized low density lipopro- rein and other pathways as well as the negative regulatory effect of zinc finger protein A20 on intestinal inflammation and epithelial apoptosis in inflammatory bowel disease.

关 键 词：锌指蛋A20 炎症反应 细胞凋亡 炎症性肠病 

分 类 号：R574[医药卫生—消化系统]