半乳糖凝集素-9与炎症性肠病关系的研究进展  

Galectin-9 and inflammatory bowel disease

作　　者：朱丽萍[1] 王鹏举[2] 刘静[1] 李林静[1] 李治国[1] 江红艳[1] 冯百岁[1] 

机构地区：[1]郑州大学第一附属医院消化内科,河南省郑州市450052 [2]郑州大学第一附属医院中英分子肿瘤学研究中心,河南省郑州市450052

出　　处：《世界华人消化杂志》2014年第4期515-520,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金面上资助项目;No.81070288;81270452;河南省医学科技攻关计划基金资助项目;No.201001004;河南省医学科技学术带头人出国培训计划基金资助项目;No.201201013~~

摘　　要：半乳糖凝集素-9(galectin-9,Gal-9)是能特异性识别、结合半乳糖苷的半乳糖凝集素家族成员之一.该蛋白广泛表达于机体组织,参与细胞生长、分化、黏附、聚集、凋亡等,与炎症性疾病、自身免疫性疾病、肿瘤、细菌病毒感染等多类疾病密切相关.近年研究发现,G a l-9与炎症性肠病的发生、发展关系密切,本文就Gal-9与炎症性肠病的关系进行综述.Galectin-9 （Gal-9）, a beta-galactoside binding lectin, is a tandem-repeat-type member of the galectin family which can specifically recog- nize and bind to galactosidase associated with diverse biological processes. Gal-9 is widely expressed in various tissues, plays a role in cell growth, polarization, adhesion, aggregation, andapoptosis, and has important functions in in- flammatory diseases, autoimmune diseases, tu- mors, and infections. Our recent studies showed that Gal-9 is strongly associated with the genesis and development of inflammatory bowel dis- ease. Here we will review the progress in under- standing the role of Gal-9 in the pathogenesis of inflammatory bowel disease.

关 键 词：半乳糖凝集素-9 炎症性肠病 TIM-3 免疫 

分 类 号：R574[医药卫生—消化系统]