IL-18与肝癌家族聚集性的相关性  

Correlation between IL-18 and familial aggregation of hepatocellular carcinoma

作　　者：莫金英 吴继周[1] 吴健林[1] 韦颖华[1] 张鹭[1] 宁秋悦[1] 胡蝶飞[1] 万裴琦[1] 

机构地区：[1]广西医科大学第一附属医院感染性疾病科,广西壮族自治区南宁市530021

出　　处：《世界华人消化杂志》2014年第4期573-577,共5页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30960170;广西卫生厅重点科研课题基金资助项目;No.桂卫重200924~~

摘　　要：目的:探讨细胞因子白介素(interleukin,IL)-18的表达水平与肝癌家族聚集性的相关性.方法:在广西肝癌高发区利用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测108对经配对设计的肝癌高发家族和无癌家族成员外周血清IL-18的水平.结果:肝癌高发家族组中不论从总体上比较还是从性别、HBsAg感染情况、年龄上分层比较,细胞因子IL-18的表达水平均显著低于无癌家族成员组(P<0.05);在肝癌高发家族组中,一级亲属与二级亲属成员之间血清IL-18的表达水平有显著性差异(t=-2.713,P=0.032);肝癌高发家族组中随着家族中肝癌患病人数的增加,IL-18的表达水平下降(Z=-2.09,P=0.037).结论:细胞因子IL-18与肝癌家族聚集性密切相关,IL-18可能是降低肝癌发生风险的一个保护性因子.AIM： To investigate the correlation between serum level of cytokine interleukin （IL）-18 and familial aggregation of hepatocellular carcinoma （HCC）. METHODS： Enzyme-linked immunosorbent as- say （ELISA） was used to detect serum levels of IL-18 in 108 pairs of carcinoma-free members from HCC high-incidence families and those from carcinoma-free families. RESULTS： Serum levels of cytokine IL-18 weresignificantly lower in carcinoma-free members from HCC high-incidence families than in those from carcinoma-free families （P 〈 0.05）, irregard- less of sex, HBsAg infection and age. In carci- noma-free members from HCC high-incidence families, the levels of IL-18 were significantly different between first-degree relatives and the second-degree relatives （t = -2.713, P = 0.032）. The level of IL-18 declined with the increase in the number of HCC patients in HCC high- incidence families （Z=-2.09, P = 0.037）. CONCLUSION： IL-18 might have a close rela- tionship to the familial aggregation of HCC, and IL-18 may be a protective factor against HCC.

关 键 词：细胞因子 白介素-18 家族聚集性 肝细胞肝癌 

分 类 号：R735.7[医药卫生—肿瘤]