子宫内膜样腺癌中CLIC1蛋白的表达及临床意义  

Expression and significance of CLIC1 protein in endometrioid adenocarcinoma

作　　者：张宾[1] 李畅[1] 贾雪峰[1] 刘宁[1] 黄庆玉[2] 

机构地区：[1]山东济宁济宁市第一人民医院肿瘤科,272111 [2]泰山医学院病理教研室,271000

出　　处：《临床肿瘤学杂志》2014年第1期49-51,共3页Chinese Clinical Oncology

摘　　要：目的探讨细胞内氯离子通道蛋白1(CLIC1)在子宫内膜样腺癌中的表达及其与临床病理特征的关系。方法采用免疫组化SP法检测100例子宫内膜样腺癌组织和50例正常子宫内膜组织中CLIC1蛋白的表达,并分析其表达与子宫内膜样腺癌临床病理特征的关系。结果 CLIC1蛋白在子宫内膜样腺癌组织中的阳性表达率为63.0%,高于其在正常子宫内膜组织中的22.0%(P<0.05);CLIC1蛋白在子宫内膜样腺癌中的表达与病理分期及淋巴结转移有关(P<0.05),而与年龄、是否绝经、浸润深度和组织学分级无关(P>0.05)。结论 CLIC1蛋白过表达可能促进了子宫内膜样腺癌的发生、发展。Objective To investigating the expression of chloride intracellular channel 1 （ CLIC1 ） in endometriuid adenocar- cinoma tissue, and analyze the relationship of its expression with clinicopathologic features. Methods The expression of CLIC1 among 100 cases of endometrioid adenocarcinoma and 50 cases of normal endometrioid tissues were tested by SP method, and the correalation of the expression of CLIC1 in endometrioid ad with clinicopathulogic features was further studied. Results The positive rate of CLIC 1 was 63.0% in endometrioid adenocarcinoma, higher than 22. 0% of normal endometrioid tissue （P〈0. 05）. The expres- sion of CLIC1 was related with pathological staging and lymph node metastasis （P〈0.05） , but not with age, menopause, histological grade and depth of invasion （P〉0. 05）. Conclusion The higher expression of CLIC 1 may accelerate the occurrence and development of endometrioid adenocarcinoma.

关 键 词：细胞内氯离子通道蛋白1 子宫内膜样腺癌 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]