去整合素蛋白酶23在结直肠癌肝转移中的表达及意义  

Expression and significance of ADAM23 in colorectal carcinoma with liver metastasis

作　　者：张明坤[1] 李胜龙[1] 王夫景[1] 杨维良[1] 

机构地区：[1]哈尔滨医科大学附属第二医院普外三科,150086

出　　处：《临床外科杂志》2014年第1期40-42,共3页Journal of Clinical Surgery

基　　金：黑龙江省自然基金资助项目（D201002）

摘　　要：目的 探讨抑癌基因去整合素蛋白酶23（ADAM23）的表达与结直肠癌肝转移发生发展的关系.方法 应用免疫组织化学和荧光实时定量PCR方法 分析31例结直肠癌患者的癌组织、肝转移灶组织和正常结直肠黏膜组织中的ADAM23蛋白和mRNA表达情况.结果 ADAM23蛋白和mRNA在结直肠癌组织和肝转移癌组织中的表达明显低于正常结直肠癌黏膜组织（P〈0.05）;肝转移癌组织中ADAM23蛋白和mRNA的表达明显低于结直肠癌组织（P〈0.05）.结论 ADAM23的异常表达可能在结直肠癌及其肝转移的发生发展中起重要作用.Objective To explore the relationship between ADAM23 expression and liver metas- tasis development in colorectal cancer. Methods Immunohistochemistry and real-time fluorescence quan- titative PCR were used to detect the expression of ADAM23 protein and mRNA in eolorectal cancer ,meta- static liver cancer and normal colorectal mucosa tissues of 31 patients. Results The expression of AD- AM23 protein and mRNA in normal colorectal mucosa tissues was significantly higher than that in colorec- tal cancer and metastatic liver cancer（P 〈 0.05 ）. The expression of ADAM23 protein and mRNA in color- ectal cancer was significantly higher than that in metastatic liver cancer （ P 〈 0.05 ）. Conclusion The ab- normal expression of ADAM23 might play an important role in genesis, progression and metastasis of color- ectal carcinoma.

关 键 词：ADAM23 结直肠癌 肝转移癌 免疫组化 实时定量PCR 

分 类 号：R735.35[医药卫生—肿瘤]